Beschreibung:
1. The method sets the tone -- 2. Preclinical studies design and place of rodents -- 3. Preclinical studies design and place of rabbits -- 4. Preclinical studies design and place of swine -- 5. Preclinical studies in the canine model -- 6. Preclinical studies design and place of caprine and ovine -- 7. Clinical investigations in implant dentistry:experimentation versus observation and the future of merging data -- 8. Translational aspects in living mammalian organisms -- 9. Biomechanics of the radicular component of endosteal implants -- 10. Radiographic imaging in implant dentistry -- 11. Biological events at the interface between the radicular part of the implant and bone -- 12. Mechanics of the implant-abutment-connection -- 13. Mechanics of the prosthetic rehabilitations -- 14. Imaging of non resorbable bone substitutes -- 15. Biology of low-substitution bone substitutes -- 16. Imaging of resorbable bone substitutes -- 17. Biology of resorbable bone substitutes -- 18. Membranes and soft tissues enhancers -- 19. Biomarkers for implant dentistry studies -- 20. Computer-Assisted Implant Dentistry -- 21. Insight into statistical procedure.
This book explores, in a comprehensive and systematic manner, Surgical Research methodologies to the design and development of investigational studies in the field of implant-based oral rehabilitation. Such studies are linked in a chain binding in vitro, in vivo, ex vivo, and digital evaluations. An ambitious objective consists in exposing how investigators can generate and deliver knowledge by capturing synergy coming from preclinical and clinical trials. Accordingly, throughout the book, translational aspects are closely scrutinized. The opening chapters consider materials, methods and procedures for preclinical and clinical studies in which approaches and models are extensively described. The focus then moves to the process by which application of histology, biomechanics, biomarkers, cellular/molecular biology, and imaging technologies lead to new results and consequently novel treatment concepts in implant dentistry, implant borne prosthetic rehabilitations and the replacement or regeneration of tissues. Finally, the exciting opportunities afforded by the digital world are addressed. This book shall be a valuable resource and time-saving tool for a wide audience of researchers, students, practitioners, and academics.