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Radermacher, Anne [VerfasserIn]; Fehrenz, Michael [VerfasserIn]; Bellin, Tamara [VerfasserIn]; Claßen, Carolina [VerfasserIn]; Möllers, Laura Christin [VerfasserIn]; Struckmeier, Ann-Kristin [VerfasserIn]; Wagner, Mathias [VerfasserIn]; Wartenberg, Philipp [VerfasserIn]; Moratin, Julius [VerfasserIn]; Freudlsperger, Christian [VerfasserIn]; Freier, Kolja [VerfasserIn]; Horn, Dominik [VerfasserIn]

HLA-E and its soluble form as indicators of a sex-specific immune response in patients with rral squamous cell carcinoma

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  • Medientyp: E-Artikel
  • Titel: HLA-E and its soluble form as indicators of a sex-specific immune response in patients with rral squamous cell carcinoma
  • Weitere Titel: Titel des special issue: Oral Squamous Cell Carcinoma—Pathogenetic, Diagnostic and Therapeutic Perspectives
  • Beteiligte: Radermacher, Anne [VerfasserIn]; Fehrenz, Michael [VerfasserIn]; Bellin, Tamara [VerfasserIn]; Claßen, Carolina [VerfasserIn]; Möllers, Laura Christin [VerfasserIn]; Struckmeier, Ann-Kristin [VerfasserIn]; Wagner, Mathias [VerfasserIn]; Wartenberg, Philipp [VerfasserIn]; Moratin, Julius [VerfasserIn]; Freudlsperger, Christian [VerfasserIn]; Freier, Kolja [VerfasserIn]; Horn, Dominik [VerfasserIn]
  • Erschienen: 24 November 2023
  • Erschienen in: International journal of molecular sciences ; 24(2023), 23, special issue, Artikel-ID 16699, Seite 1-13
  • Sprache: Englisch
  • DOI: 10.3390/ijms242316699
  • ISSN: 1422-0067
  • Identifikator:
  • Schlagwörter: HLA-E ; immunotherapy ; oral squamous cell carcinoma (OSCC) ; sex-related differences in immune response ; soluble HLA-E
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in scientific focus. Therefore, immunohistochemical HLA-E expression was retrospectively analysed in a cohort of oral squamous cell carcinomas (OSCC) after surgical therapy. Then, serum concentration of HLA-E (sHLA-E) was quantified in a prospective cohort by enzyme-linked immunosorbent assay. High HLA-E expression was associated with advanced UICC stage (Spearman’s correlation: p = 0.002) and worse survival (Cox-regression: progression-free survival: hazard ratio (HR) 3.129, confidence range (CI) 1.443-6.787, p = 0.004; overall survival: HR 2.328, CI 1.071-5.060, p = 0.033). The sHLA-E concentration was significantly higher in the control group than in tumor group (Mann-Whitney U-test (MW-U): p = 0.021). Within the tumor group, women showed significantly higher sHLA-E levels than men (MW-U: p = 0.049). A closer look at the tumor group and the control group showed that gender-specific differences exist: while no differences in sHLA-E concentration were detectable between female subjects of tumor group and control group (MW-U: p = 0.916), male subjects of tumor group had a significantly lower sHLA-E concentration compared to those of control group (MW-U: p = 0.001). In summary, our results provide evidence for sex-specific differences in immune responses in OSCC. This fact should be considered regarding future immunotherapy regimens.
  • Zugangsstatus: Freier Zugang