Beschreibung:
Introduction: An enhanced understanding of the molecular pathways driving oncogenesis has yielded an increasing number of potential therapeutic targets. MET amplification has been shown to be involved in angiogenesis, cell proliferation, migration, and invasion, as well as cell survival. A pathologic activation of c-MET pathway may occur via met gene amplification, RNA transcription or protein overexpression. This study focused on the relationship between MET-amplification and one of the most prevalent malignancies worldwide- the colorectal carcinoma (CRC). Systemic antibody therapies targe...