Beschreibung:
The cytoskeleton is a pivotal structure within cells, crucial for their motion and life-indispensable processes. The actin cortex is a dense actin network that is part of the cytoskeleton and linked to the plasmamembrane. ERM (ezrin, radixin and moesin) proteins are central for the connection between the actin cortex and plasmamembrane. Ezrin recruits filamentous actin (f-actin) to the plasmamembrane resulting in the formation of actin cortex structures. In vivo, ezrin is activated in a two step mechanism. First, ezrin binds with its N-terminal domain (ezrin-FERM) to L-α -phosphatidylinosit...