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Kühl, Rea [VerfasserIn]; Feyer, Jule [VerfasserIn]; Limbach, Matthias [VerfasserIn]; Pahl, Antonia [VerfasserIn]; Stoelzel, Friederike [VerfasserIn]; Beck, Heidrun [VerfasserIn]; Wegner, Annika [VerfasserIn]; Rosenberger, Friederike [VerfasserIn]; Dreger, Peter [VerfasserIn]; Luft, Thomas [VerfasserIn]; Wiskemann, Joachim [VerfasserIn]

Prehabilitative high-intensity interval training and resistance exercise in patients prior allogeneic stem cell transplantation

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  • Medientyp: E-Artikel
  • Titel: Prehabilitative high-intensity interval training and resistance exercise in patients prior allogeneic stem cell transplantation
  • Beteiligte: Kühl, Rea [VerfasserIn]; Feyer, Jule [VerfasserIn]; Limbach, Matthias [VerfasserIn]; Pahl, Antonia [VerfasserIn]; Stoelzel, Friederike [VerfasserIn]; Beck, Heidrun [VerfasserIn]; Wegner, Annika [VerfasserIn]; Rosenberger, Friederike [VerfasserIn]; Dreger, Peter [VerfasserIn]; Luft, Thomas [VerfasserIn]; Wiskemann, Joachim [VerfasserIn]
  • Erschienen: 12 December 2023
  • Erschienen in: Scientific reports ; 13(2023), Artikel-ID 22069, Seite 1-10
  • Sprache: Englisch
  • DOI: 10.1038/s41598-023-49420-7
  • ISSN: 2045-2322
  • Identifikator:
  • Schlagwörter: Cancer ; Haematological cancer ; Oncology
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Physical capacity prior allogeneic stem cell transplantation (allo-HCT) has been shown as a relevant prognostic factor for survival after transplant. Therefore, we evaluated feasibility and preliminary efficacy of a high-intensity interval training (HIIT) and moderate to high-intensity resistance exercise (RE) to increase physical capacity in patient’s prior allo-HCT. In this multicentre single arm pilot study, a supervised exercise program was performed twice weekly for 4-12 weeks prior allo-HCT, depending on the individual time remaining. Outcomes were feasibility (recruitment, adherence, safety), physical capacity (cardiorespiratory fitness [VO2peak], muscle strength) and patient reported outcomes (physical functioning, fatigue). Thirty patients were intended, 16 could be included, and 14 completed post intervention assessment (75% male, 55 ± 11 years). The study was stopped early due to a low recruitment rate. Nine patients (64%) reached the initial minimum planned number of eight exercise sessions. Individual adherence was high with 92% for HIIT and 85% for RE. 87% of all performed exercise sessions were completed without complaints and VO2peak increased significantly from 20.4 to 23.4 ml/kg/min. The low recruitment rate suggests that initiation of the intervention concept immediately before allo-HCT is feasible only in a small number of patients. In particular, the timeframe directly prior allo-HCT seems too short for exercise interventions, although the exercise program was designed to improve outcomes in a very short time frame. HIIT and RE were feasible, effective and well accepted by the included patients.
  • Zugangsstatus: Freier Zugang