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Botta, Cirino
[Verfasser:in];
Perez, Cristina
[Verfasser:in];
Larrayoz, Marta
[Verfasser:in];
Puig, Noemi
[Verfasser:in];
Cedena, Maria-Teresa
[Verfasser:in];
Termini, Rosalinda
[Verfasser:in];
Goicoechea, Ibai
[Verfasser:in];
Rodriguez, Sara
[Verfasser:in];
Zabaleta, Aintzane
[Verfasser:in];
Lopez, Aitziber
[Verfasser:in];
Sarvide, Sarai
[Verfasser:in];
Blanco, Laura
[Verfasser:in];
Papetti, Daniele M.
[Verfasser:in];
Nobile, Marco S.
[Verfasser:in];
Besozzi, Daniela
[Verfasser:in];
Gentile, Massimo
[Verfasser:in];
Correale, Pierpaolo
[Verfasser:in];
Siragusa, Sergio
[Verfasser:in];
Oriol, Albert
[Verfasser:in];
González-Garcia, Maria Esther
[Verfasser:in];
Sureda, Anna
[Verfasser:in];
de Arriba, Felipe
[Verfasser:in];
Rios Tamayo, Rafael
[Verfasser:in];
Moraleda, Jose-Maria
[Verfasser:in];
[...]
Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
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- Medientyp: E-Artikel
- Titel: Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
- Beteiligte: Botta, Cirino [Verfasser:in]; Perez, Cristina [Verfasser:in]; Larrayoz, Marta [Verfasser:in]; Puig, Noemi [Verfasser:in]; Cedena, Maria-Teresa [Verfasser:in]; Termini, Rosalinda [Verfasser:in]; Goicoechea, Ibai [Verfasser:in]; Rodriguez, Sara [Verfasser:in]; Zabaleta, Aintzane [Verfasser:in]; Lopez, Aitziber [Verfasser:in]; Sarvide, Sarai [Verfasser:in]; Blanco, Laura [Verfasser:in]; Papetti, Daniele M. [Verfasser:in]; Nobile, Marco S. [Verfasser:in]; Besozzi, Daniela [Verfasser:in]; Gentile, Massimo [Verfasser:in]; Correale, Pierpaolo [Verfasser:in]; Siragusa, Sergio [Verfasser:in]; Oriol, Albert [Verfasser:in]; González-Garcia, Maria Esther [Verfasser:in]; Sureda, Anna [Verfasser:in]; de Arriba, Felipe [Verfasser:in]; Rios Tamayo, Rafael [Verfasser:in]; Moraleda, Jose-Maria [Verfasser:in]; Gironella, Mercedes [Verfasser:in]; Hernandez, Miguel T. [Verfasser:in]; Bargay, Joan [Verfasser:in]; Palomera, Luis [Verfasser:in]; Pérez-Montaña, Albert [Verfasser:in]; Goldschmidt, Hartmut [Verfasser:in]; Avet-Loiseau, Hervé [Verfasser:in]; Roccaro, Aldo [Verfasser:in]; Orfao, Alberto [Verfasser:in]; Martinez-Lopez, Joaquin [Verfasser:in]; Rosiñol, Laura [Verfasser:in]; Lahuerta, Juan-José [Verfasser:in]; Blade, Joan [Verfasser:in]; Mateos, Maria-Victoria [Verfasser:in]; San-Miguel, Jesús F. [Verfasser:in]; Martinez Climent, Jose-Angel [Verfasser:in]; Paiva, Bruno [Verfasser:in]
-
Erschienen:
20 September 2023
- Erschienen in: Nature Communications ; 14(2023), Artikel-ID 5825, Seite 1-15
- Sprache: Englisch
- DOI: 10.1038/s41467-023-41562-6
- Identifikator:
- Schlagwörter: Myeloma ; Tumour immunology ; VDJ recombination
- Entstehung:
- Hochschulschrift:
- Anmerkungen:
- Beschreibung: Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). Here, we use single-cell RNA and T cell receptor sequencing to characterize bone marrow T cells from healthy adults (n = 4) and patients with precursor (n = 8) and full-blown MM (n = 10). Large T cell clones from patients with MM expressed multiple immune checkpoints, suggesting a potentially dysfunctional phenotype. Dual targeting of PD-1 + LAG3 or PD-1 + TIGIT partially restored their function in mice with MM. We identify phenotypic hallmarks of large intratumoral T cell clones, and demonstrate that the CD27− and CD27+ T cell ratio, measured by flow cytometry, may serve as a surrogate of clonal T cell expansions and an independent prognostic factor in 543 patients with MM treated with lenalidomide-based treatment combinations.
- Zugangsstatus: Freier Zugang