Beschreibung:
Multiple Sclerosis is a complex and challenging chronic disease of the central nervous system (CNS), characterized by inflammation, demyelination, and neurodegeneration. The depletion of B cells using anti-CD20 antibodies as therapeutic strategy, has proven to be highly effective. However, in the long-term, a complete absence of B cells does not come without adverse side effects, and in addition, B cell subpopulations appear to be capable of providing regulatory properties. Consequently, there is an increasing emphasis on modulating B cell functions rather than entirely eliminating these im...