Beschreibung:
The approach of this study was to examine the influence of neprilysin on the pathogenesis of sporadic Alzheimer’s disease. In three parts, this study combined standard histologic, immunohistochemical and in-vitro proteolysis experiments. The Tg4-42 mouse model represents an established model for the sporadic Alzheimer’s disease. Bred with neprilysin-gene knock out mice, Tg4-42/NEP-/- were generated to be compared to wildtype, NEP-/- and Tg4-42 mice. To examine age-dependent effects of neprilysin deficiency, 3-month-old and 12-month-old animals were selected for each group. In the first part...