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Medientyp:
E-Book;
Hochschulschrift
Titel:
Single-molecule measurements of complex molecular interactions in membrane proteins using atomic force microscopy
Weitere Titel:
Übers. des Hauptsacht.: Einzelmolekül-Messungen komplexer molekularer Wechselwirkungen in Membranproteinen unter Benutzung des Rasterkraftmikroskops
Hochschulschrift:
Dresden, Techn. Univ., Fak. Mathematik und Naturwiss., Diss., 2007
Anmerkungen:
Beschreibung:
Single-molecule force spectroscopy (SMFS) with atomic force microscope (AFM) has advanced our knowledge of the mechanical aspects of biological processes, and helped us take big strides in the hitherto unexplored areas of protein (un)folding. One such virgin land is that of membrane proteins, where the advent of AFM has not only helped to visualize the difficult to crystallize membrane proteins at the single-molecule level, but also given a new perspective in the understanding of the interplay of molecular interactions involved in the construction of these molecules. My PhD work was tightly focused on exploiting this sensitive technique to decipher the intra- and intermolecular interactions in membrane proteins, using bacteriorhodopsin and bovine rhodopsin as model systems...
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