• Medientyp: E-Book; Hochschulschrift
  • Titel: Role of Pax6 in pancreatic endocrine cell subtype specification
  • Beteiligte: Ahmad, Zeeshan [VerfasserIn]; Mansouri, Ahmed [Betreuer]; Engel, Wolfgang [Gutachter]; Dressel, Ralf [Gutachter]
  • Erschienen: 2013
  • Umfang: Online-Ressource (PDF-Datei: 4,2 MB)
  • Sprache: Englisch
  • Identifikator:
  • Schlagwörter: Hochschulschrift
  • Entstehung:
  • Hochschulschrift: Göttingen, Univ., Diss., 2013
  • Anmerkungen:
  • Beschreibung: Pax6, a transcription factor from the paired box gene family is expressed in the endocrine pancreas and is required for its proper development. As Pax6 classical and pancreas-specific conditional knockout mice die early after birth, it is not possible to analyze the role of Pax6 in adult endocrine cell function. Therefore, we generated non-inducible alpha-cell-specific and inducible beta-cell-specific Pax6 knockout mice to observe the cell-type-specific effect of Pax6 ablation. Following Pax6 ablation, the adult beta-cells lost their mature differentiation state and function. This was evide...
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