• Medientyp: E-Book; Hochschulschrift
  • Titel: The role and regulation of histone H2B monoubiquitination during tumorigenesis
  • Beteiligte: Gorsler, Theresa [VerfasserIn]; Johnsen, Steven Prof. [Betreuer]; Johnsen, Steven Prof. [Gutachter]; Reichardt, Holger [Gutachter]; Kube, Dieter [Gutachter]
  • Erschienen: 2013
  • Umfang: Online-Ressource (PDF-Datei: 3,8 MB)
  • Sprache: Deutsch
  • Identifikator:
  • Schlagwörter: Hochschulschrift
  • Entstehung:
  • Hochschulschrift: Göttingen, Univ., Diss., 2013
  • Anmerkungen:
  • Beschreibung: Posttranslational histone modifications are recognized as important regulators of gene expression. One of them, the monoubiquitination of lysine 120 of histone H2B (H2Bub1), has diverse functions and is involved in gene transcription as well as in controlling mRNA processing, DNA repair and DNA replication. Notably, H2Bub1 is associated with actively transcribed genes and has been linked to ongoing transcription. The misregulation of H2Bub1-modifying machinery has been observed to be tightly linked with different types of cancer. In the course of this study we clarified aspects of the regul...
  • Zugangsstatus: Freier Zugang