Sprenger, Julia U.
[VerfasserIn]
;
Nikolaev, Viacheslav
[AkademischeR BetreuerIn];
Nikolaev, Viacheslav
[Sonstige Person, Familie und Körperschaft];
Schu, Peter
[Sonstige Person, Familie und Körperschaft]
Local cAMP dynamics in the SERCA2a signalling complex
Beschreibung:
3’,5’-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that regulates multiple physiological functions by acting in distinct subcellular microdomains. Over the last few years, several targeted biosensors have been developed and used in cell lines or neonatal cardiomyocytes to investigate the molecular mechanisms behind cAMP compartmentation. However, it is unclear whether such biosensors can be successfully used for expression in vivo, especially in the context of disease such as cardiac hypertrophy. Importantly, cAMP regulates cardiac function by acting in distinct su...