• Medientyp: E-Book; Hochschulschrift
  • Titel: Die anti-tumorale Wirkung des neuen Phosphoinositid-3-Kinase-Inhibitors BAY 80-6946 auf humane Myelom-Zellen
  • Weitere Titel: Nebentitel: The anti-tumour activity of the novel PI3K inhibitor BAY 80-6946 on myeloma cells
  • Beteiligte: Hensen, Janina [VerfasserIn]; Schön, Margarete [Betreuer]; Schön, Michael [Gutachter]; Bastians, Holger [Gutachter]; Oppermann, Martin [Gutachter]
  • Erschienen: 2014
  • Umfang: Online-Ressource
  • Sprache: Deutsch
  • Identifikator:
  • Schlagwörter: Hochschulschrift
  • Entstehung:
  • Hochschulschrift: Göttingen, Univ., Diss., 2015
  • Anmerkungen:
  • Beschreibung: Overcoming drug resistance in the bone marrow microenvironment is an unresolved challenge in therapy of multiple myeloma. Despite numerous therapeutic approaches with new agents targeting the bone marrow microenvironment multiple myeloma still remains an incurable condition. Multiple myeloma cells exhibit numerous mechanisms of drug resistance. Constitutive activation of the Phosphatidylinositol-3-kinase (PI3K) is associated with tumour progression in multiple myeloma. Targeting the PI3K/Akt pathway can induce apoptosis in multiple myeloma cells. Therefore the use of PI3K inhibitors is pred...
  • Zugangsstatus: Freier Zugang