Crystal structures of a bacterial isocitrate dehydrogenase and the human sulfamidase: pushing the limits of molecular replacement

Medientyp: E-Book; Hochschulschrift

Titel: Crystal structures of a bacterial isocitrate dehydrogenase and the human sulfamidase : pushing the limits of molecular replacement

Beteiligte: Sidhu, Navdeep Singh [VerfasserIn]; Sheldrick, George [Betreuer]; Ficner, Ralf [Gutachter]; Tittmann, Kai [Gutachter]; Laatsch, Hartmut [Gutachter]; Dittrich, Priv. [Gutachter]; Fabbiani, Francesca [Gutachter]

Erschienen: 2013

Umfang: Online-Ressource (PDF-Datei: 107,0 MB)

Sprache: Englisch

Identifikator:

Schlagwörter: Hochschulschrift

Entstehung:

Hochschulschrift: Göttingen, Univ., Diss., 2013

Anmerkungen:

Beschreibung: In an X-ray crystallographic experiment, intensities and directions of X-rays scattered by electrons in a crystal are measured. However, the relative phase information in the interference pattern is lost. If we knew the phases, we could calculate the electron density in the crystal, fit an atomic model to the density and thus solve the three-dimensional structure of the substance forming the crystal. One method of deriving the phase information is called molecular replacement (MR). In this method, the diffraction data are used to correctly position in the crystal a search model that is deri...

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