Endothelial transformation related protein 53 deletion promotes angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice

Medientyp: E-Book; Hochschulschrift

Titel: Endothelial transformation related protein 53 deletion promotes angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice

Beteiligte: Gogiraju, Rajinikanth [Verfasser:in]; Dobbelstein, Matthias [Akademische:r Betreuer:in]; Kessel, Michael [Akademische:r Betreuer:in]; Zimmermann, Wolfram-Hubertus [Akademische:r Betreuer:in]; Zeisberg, Michael [Akademische:r Betreuer:in]; Lutz, Susanne [Akademische:r Betreuer:in]; Schäfer, Katrin [Akademische:r Betreuer:in]

Erschienen: 2015

Umfang: Online-Ressource

Sprache: Englisch

Identifikator:

Schlagwörter: Hochschulschrift

Entstehung:

Hochschulschrift: Dissertation, Georg-August-Universität Göttingen, 2015

Anmerkungen:

Beschreibung: Background− Accumulation of transformation related protein 53 (p53), apoptotic cell death and rarefication of myocardial angiogenesis may be involved in the development of cardiac dysfunction during chronic pressure overload. Objective− The aim of this study was to determine whether prevention of endothelial cell apoptosis deletion of p53 in endothelial cells improves cardiac remodeling during pressure overload and prevents the transition from hypertrophy to heart failure. Methods and Results− Mice with endothelial deletion of p53 (End.p53-KO) were generated by crossing p53fl/fl mice with ...

Zugangsstatus: Freier Zugang

Nur in Feld suchen:

Zuletzt gesuchte Begriffe: