• Medientyp: E-Book; Hochschulschrift
  • Titel: The role of membrane transporters in the pharmacokinetics of psychotropic drugs: in vitro studies with special focus on organic cation transporters
  • Beteiligte: Santos Pereira, João Nuno dos [VerfasserIn]; Brockmöller, Jürgen [Betreuer]; Burckhardt, Gerhard [Gutachter]; Hanisch, Uwe-Karsten [Gutachter]
  • Erschienen: 2015
  • Umfang: Online-Ressource
  • Sprache: Englisch
  • Identifikator:
  • Schlagwörter: Hochschulschrift
  • Entstehung:
  • Hochschulschrift: Göttingen, Univ., Diss., 2015
  • Anmerkungen:
  • Beschreibung: The treatment of common psychiatric disorders like major depression, schizophrenia and bipolar disorder is characterized by low efficacy and variability in the case of depression and bipolar disorder, and of undesirable side effects in the case of schizophrenia. One of the explanations is that the drug may not be reaching its site of action, at concentrations that are high enough to provoke a response. On the other hand, poor elimination of the drug from the body may lead to high plasma concentrations, which may cause undesirable side effects. Variations in membrane transport at the blood-b...
  • Zugangsstatus: Freier Zugang