• Medientyp: E-Book; Hochschulschrift
  • Titel: Identification of molecular role of Pelota protein in proliferation and differentiation of male germ stem cells by analysis of conditional knock-out mice
  • Beteiligte: Raju, Priyadharsini [Sonstige Person, Familie und Körperschaft]; Brenig, Bertram [Betreuer]; Engel, Wolfgang [Gutachter]; Adham, Ibrahim [Gutachter]
  • Erschienen: 2015
  • Umfang: Online-Ressource (PDF-Datei: 11,2 MB)
  • Sprache: Englisch
  • Identifikator:
  • Schlagwörter: Hochschulschrift
  • Entstehung:
  • Hochschulschrift: Göttingen, Univ., Diss., 2015
  • Anmerkungen: Kumulative Arbeit
  • Beschreibung: Pelota (Pelo) is an evolutionally conserved gene, which has been characterized in various species. In Drosophila, Pelo deficiency affects both male and female fertility. The molecular function of PELO has been extensively characterized in yeast, where PELO ortholog Dom34 and its interacting partner Hbs1 participate in RNA quality control mechanism named No-Go decay (NGD). In mice, genetic ablation of Pelo leads to embryonic lethality at the early implantation stage as a result of the impaired development of extra-embryonic endoderm (ExEn). The in vitro culture of Pelo-null blastocysts revea...
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