Characterization of exosomes as a diagnostic marker in neurodegenerative diseases

Medientyp: E-Book; Hochschulschrift

Titel: Characterization of exosomes as a diagnostic marker in neurodegenerative diseases

Beteiligte: Stündl, Anne-Katrin [VerfasserIn]; Simons, Mikael [AkademischeR BetreuerIn]; Simons, Mikael [Gutachter]; Schwappach, Blanche [Gutachter]; Schneider, Anja [Gutachter]

Erschienen: 2016

Umfang: 1 Online-Ressource

Sprache: Englisch

Identifikator:

Schlagwörter: Hochschulschrift

Entstehung:

Hochschulschrift: Dissertation, Georg-August-Universität Göttingen, 2016

Anmerkungen:

Beschreibung: α-Synuclein pathology has been hypothesized to propagate in synucleinopathies by intercellular transfer of pathogenic seeds in a prion-like fashion. Extracellular release of α-Synuclein via small extracellular vesicles has been proposed as one of the mechanisms of cell-to-cell disease transmission. In vitro, extracellular α-Synuclein has been detected in exosomal vesicles and we have recently provided evidence that α-Synuclein is present in exosomes in the central nervous system in vivo. We hypothesized that exosomes from patients with α Synuclein related neurodegeneration serve as carriers...

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