Engelhard, David Maximilian
[Verfasser:in]
;
Clever, Guido
[Akademische:r Betreuer:in];
Clever, Guido
[Sonstige Person, Familie und Körperschaft];
Höbartner, Claudia
[Sonstige Person, Familie und Körperschaft]
Synthesis and coordination chemistry of tetradentate chelators based on ligand-appended G-quadruplex structures
Beschreibung:
In this thesis, the concept of metal base-pairing was adapted for usage with the DNA secondary structure of G-quadruplexes. Apart from the well-known B-DNA double helix, oligonucleotides can form a variety of different topologies. G-quadruplexes self-assemble from guanine-rich DNA strands forming G-quartets, which stack on top of each other, and are believed to play an important biological role, e. g. during DNA transcription, replication and telomere maintenance. The unique folding behaviour of G-quadruplexes was used to establish a “metal base-tetrad” motif in analogy to the metal base-pa...