Mishra, Vivek Kumar
[Verfasser:in]
;
Johnsen, Steven
[Akademische:r Betreuer:in];
Johnsen, Steven
[Sonstige Person, Familie und Körperschaft];
Dobbelstein, Matthias
[Sonstige Person, Familie und Körperschaft]
Beschreibung:
The Transforming Growth Factor-β (TGFβ)/SMAD signaling pathway can function as either a tumor suppressor or metastasis promoter during tumor progression. In normal epithelial cells and early stages of epithelial tumorigenesis TGFβ functions as a tumor suppressor to decrease cell proliferation or induce apoptosis. However, during malignant progression tumor cells no longer respond to the anti-proliferative effects of TGFβ, but instead undergo an epithelial-to-mesenchymal transition (EMT) whereby cells acquire a migratory and invasive phenotype which promotes tumor metastasis. Resolution of t...