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In this paper, we consider the following three dimensional defocusing cubic nonlinear Schrödinger equation (NLS) with partial harmonic potential $\begin{equation} \left\{\begin{array}{l} i\partial_tu + \left(\Delta_{\mathbb{R}^3}-x^2\right)u = |u|^2u, \\ u|_{t=0} = u_0 \\ \end{array}\right. \tag{NLS} \end{equation}$ Out main result shows that the solution $u$ scatters for any given initial data $u_0$ with finite mass and energy. The main new ingredient in our approach is to approxmate (NLS) in the large-scale case by a relevant dispersive continuous resonant (DCR) system. The proof of global well-posedness and scattering of the new (DCR) system is greatly inspired by the fundamental works of Dodson [29, 31, 32] in his study of scattering for the mass-critical nonlinear Schrödinger equation. The analysis of (DCR) system allows us to utilize the additional regularity of the smooth nonlinear profile so that the celebrated concentration-compactness/rigidity argument of Kenig and Merle [61,62] applies.