> Detailanzeige

Schuh, Sandra [VerfasserIn]; Sattler, Elke Christina [VerfasserIn]; Rubeck, Anna [VerfasserIn]; Schiele, Stefan [VerfasserIn]; De Carvalho, Nathalie [VerfasserIn]; Themstrup, Lotte [VerfasserIn]; Ulrich, Martina [VerfasserIn]; Jemec, Gregor B. E. [VerfasserIn]; Holmes, Jon [VerfasserIn]; Pellacani, Giovanni [VerfasserIn]; Welzel, Julia [VerfasserIn]

Dynamic optical coherence tomography of blood vessels in cutaneous melanoma — correlation with histology, immunohistochemistry and dermoscopy

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Dynamic optical coherence tomography of blood vessels in cutaneous melanoma — correlation with histology, immunohistochemistry and dermoscopy
  • Beteiligte: Schuh, Sandra [VerfasserIn]; Sattler, Elke Christina [VerfasserIn]; Rubeck, Anna [VerfasserIn]; Schiele, Stefan [VerfasserIn]; De Carvalho, Nathalie [VerfasserIn]; Themstrup, Lotte [VerfasserIn]; Ulrich, Martina [VerfasserIn]; Jemec, Gregor B. E. [VerfasserIn]; Holmes, Jon [VerfasserIn]; Pellacani, Giovanni [VerfasserIn]; Welzel, Julia [VerfasserIn]
  • Erschienen: Augsburg University Publication Server (OPUS), 2023-08-23
  • Sprache: Englisch
  • DOI: https://doi.org/10.3390/cancers15174222
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: Dermoscopy adds important information to the assessment of cutaneous melanoma, but the risk of progression is predicted by histologic parameters and therefore requires surgery and histopathologic preparation. Neo-vascularization is crucial for tumor progression and worsens prognosis. The aim of this study was the in vivo evaluation of blood vessel patterns in melanoma with dynamic optical coherence tomography (D-OCT) and the correlation with dermoscopic and histologic malignancy parameters for the risk assessment of melanoma. In D-OCT vessel patterns, shape, distribution and presence/type of branching of 49 melanomas were evaluated in vivo at three depths and correlated with the same patterns in dermoscopy and with histologic parameters after excision. In D-OCT, blood vessel density and atypical shapes (coils and serpiginous vessels) increased with higher tumor stage. The histologic parameters ulceration and Hmb45- and Ki67-positivity increased, whereas regression, inflammation and PD-L1-positivity decreased with risk. CD31, VEGF and Podoplanin correlated with D-OCT vasculature findings. B-RAF mutation status had no influence. Due to pigment overlay and the summation effect, the vessel evaluation in dermoscopy and D-OCT did not correlate well. In summary, atypical vessel patterns in melanoma correlate with histologic parameters for risk for metastases. Tumor vasculature can be noninvasively assessed using D-OCT before surgery.
  • Zugangsstatus: Freier Zugang