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Ogada, Pamella Akoth [VerfasserIn]; Kiirika, Leonard Muriithi [VerfasserIn]; Lorenz, Christin [VerfasserIn]; Senkler, Jennifer [VerfasserIn]; Braun, Hans-Peter [VerfasserIn]; Poehling, Hans-Michael [VerfasserIn]

Differential proteomics analysis of Frankliniella occidentalis immune response after infection with Tomato spotted wilt virus (Tospovirus) - [published Version]

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  • Medientyp: E-Artikel; Sonstige Veröffentlichung
  • Titel: Differential proteomics analysis of Frankliniella occidentalis immune response after infection with Tomato spotted wilt virus (Tospovirus)
  • Beteiligte: Ogada, Pamella Akoth [VerfasserIn]; Kiirika, Leonard Muriithi [VerfasserIn]; Lorenz, Christin [VerfasserIn]; Senkler, Jennifer [VerfasserIn]; Braun, Hans-Peter [VerfasserIn]; Poehling, Hans-Michael [VerfasserIn]
  • Erschienen: Amsterdam [u.a.] : Elsevier Science, 2017
  • Erschienen in: Developmental and Comparative Immunology 67 (2017) ; Developmental and Comparative Immunology
  • Ausgabe: published Version
  • Sprache: Englisch
  • DOI: https://doi.org/10.15488/11653; https://doi.org/10.1016/j.dci.2016.10.013
  • ISSN: 0145-305
  • Schlagwörter: actin related protein 2 ; cathepsin L ; heterochromatin protein 1 ; hornerin ; transcriptome ; ribosome protein L12 ; actin ; inactive hyaluronidase B ; guanine nucleotide binding protein beta subunit ; aldose reductase related protein 1 ; Proteomics ; isoelectric focusing ; Article ; dermcidin ; Tomato spotted wilt virus ; unindexed drug ; 2D-IEF/SDS/PAGE ; proton transporting adenosine triphosphate synthase ; adenosylhomocysteinase ; fibrinogen ; ubiquitin ; guanosine phosphate reductase ; initiation factor 5A ; Innate immunity ; [...]
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  • Beschreibung: Tomato spotted wilt virus (TSWV) is mainly vectored by Frankliniella occidentalis Pergande, and it potentially activates the vector's immune response. However, molecular background of the altered immune response is not clearly understood. Therefore, using a proteomic approach, we investigated the immune pathways that are activated in F. occidentalis larvae after 24 h exposure to TSWV. Two-dimensional isoelectric focusing/sodium dodecyl sulfate polyacrylamide gel electrophoresis (2D-IEF/SDS/PAGE) combined with mass spectrometry (MS), were used to identify proteins that were differentially expressed upon viral infection. High numbers of proteins were abundantly expressed in F. occidentalis exposed to TSWV (73%) compared to the non-exposed (27%), with the majority functionally linked to the innate immune system such as: signaling, stress response, defense response, translation, cellular lipids and nucleotide metabolism. Key proteins included: 70 kDa heat shock proteins, Ubiquitin and Dermcidin, among others, indicative of a responsive pattern of the vector's innate immune system to viral infection. © 2016 Elsevier Ltd
  • Zugangsstatus: Freier Zugang