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Rodriguez-Niño, Angelica [VerfasserIn]; Pastene, Diego O. [VerfasserIn]; Post, Adrian [VerfasserIn]; Yusof Said, M. [VerfasserIn]; Gomes-Neto, Antonio W. [VerfasserIn]; Kieneker, Lyanne M. [VerfasserIn]; Heiner-Fokkema, M. Rebecca [VerfasserIn]; Esatbeyoglu, Tuba [VerfasserIn]; Rimbach, Gerald [VerfasserIn]; Schnuelle, Peter [VerfasserIn]; Yard, Benito A. [VerfasserIn]; Bakker, Stephan J. L. [VerfasserIn]

Urinary carnosinase-1 excretion is associated with urinary carnosine depletion and risk of graft failure in kidney transplant recipients: Results of the transplantlines cohort study - [published Version]

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  • Medientyp: E-Artikel; Sonstige Veröffentlichung
  • Titel: Urinary carnosinase-1 excretion is associated with urinary carnosine depletion and risk of graft failure in kidney transplant recipients: Results of the transplantlines cohort study
  • Beteiligte: Rodriguez-Niño, Angelica [VerfasserIn]; Pastene, Diego O. [VerfasserIn]; Post, Adrian [VerfasserIn]; Yusof Said, M. [VerfasserIn]; Gomes-Neto, Antonio W. [VerfasserIn]; Kieneker, Lyanne M. [VerfasserIn]; Heiner-Fokkema, M. Rebecca [VerfasserIn]; Esatbeyoglu, Tuba [VerfasserIn]; Rimbach, Gerald [VerfasserIn]; Schnuelle, Peter [VerfasserIn]; Yard, Benito A. [VerfasserIn]; Bakker, Stephan J. L. [VerfasserIn]
  • Erschienen: Basel : MDPI AG, 2021
  • Erschienen in: Antioxidants 10 (2021), Nr. 7 ; Antioxidants
  • Ausgabe: published Version
  • Sprache: Englisch
  • DOI: https://doi.org/10.15488/12398; https://doi.org/10.3390/antiox10071102
  • Schlagwörter: Oxidative stress ; Graft failure ; Carnosine ; Carnosinase-1 ; Kidney transplantation
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  • Beschreibung: Carnosine affords protection against oxidative and carbonyl stress, yet high concentrations of the carnosinase-1 enzyme may limit this. We recently reported that high urinary carnosi-nase-1 is associated with kidney function decline and albuminuria in patients with chronic kidney disease. We prospectively investigated whether urinary carnosinase-1 is associated with a high risk for development of late graft failure in kidney transplant recipients (KTRs). Carnosine and carnosi-nase-1 were measured in 24 h urine in a longitudinal cohort of 703 stable KTRs and 257 healthy controls. Cox regression was used to analyze the prospective data. Urinary carnosine excretions were significantly decreased in KTRs (26.5 [IQR 21.4–33.3] µmol/24 h versus 34.8 [IQR 25.6–46.8] µmol/24 h; p < 0.001). In KTRs, high urinary carnosinase-1 concentrations were associated with increased risk of undetectable urinary carnosine (OR 1.24, 95%CI [1.06–1.45]; p = 0.007). During median follow-up for 5.3 [4.5–6.0] years, 84 (12%) KTRs developed graft failure. In Cox regression analyses, high urinary carnosinase-1 excretions were associated with increased risk of graft failure (HR 1.73, 95%CI [1.44–2.08]; p < 0.001) independent of potential confounders. Since urinary carnosine is depleted and urinary carnosinase-1 imparts a higher risk for graft failure in KTRs, future studies determining the potential of carnosine supplementation in these patients are warranted. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)