Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis

Medientyp: E-Artikel; Sonstige Veröffentlichung

Titel: Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis

Beteiligte: Haufe, Sven [VerfasserIn]; Hupa-Breier, Katharina L. [VerfasserIn]; Bayerle, Pauline [VerfasserIn]; Boeck, Hedwig T. [VerfasserIn]; Rolff, Simone [VerfasserIn]; Sundermeier, Thorben [VerfasserIn]; Kerling, Arno [VerfasserIn]; Eigendorf, Julian [VerfasserIn]; Kück, Momme [VerfasserIn]; Hanke, Alexander A. [VerfasserIn]; Ensslen, Ralf [VerfasserIn]; Nachbar, Lars [VerfasserIn]; Lauenstein, Dirk [VerfasserIn]; Böthig, Dietmar [VerfasserIn]; Hilfiker-Kleiner, Denise [VerfasserIn]; Stiesch, Meike [VerfasserIn]; Terkamp, Christoph [VerfasserIn]; Wedemeyer, Heiner [VerfasserIn]; Haverich, Axel [VerfasserIn]; Tegtbur, Uwe [VerfasserIn]

Erschienen: London : Nature Publ. Group, 2021

Ausgabe: published Version

Sprache: Englisch

DOI: https://doi.org/10.15488/16707; https://doi.org/10.14309/ctg.0000000000000371

Schlagwörter: general health status assessment ; Exercise Therapy ; Liver ; Male ; alanine aminotransferase ; Wearable Electronic Devices ; gamma glutamyltransferase ; aminotransferase ; Adult ; Exercise ; Freiburger Physical Activity Questionnaire ; hepatitis ; Linear Models ; Humans ; hypertransaminasemia ; liver injury ; controlled study ; antihypertensive agent ; cholesterol blood level ; alkaline phosphatase ; liver fibrosis ; Obesity ; urea ; Liver Cirrhosis ; [...]

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Beschreibung: INTRODUCTION:Metabolic syndrome (MetS) is a major health problem worldwide and the main risk factor for metabolic-associated fatty liver disease (MAFLD). Established treatment options are lifestyle interventions facilitating dietary change and increased physical activity. Here, we tested the effect of a telemonitoring-supported intervention on liver parameter of inflammation and fibrosis in individuals with MetS.METHODS:This was a prospective, randomized, parallel-group, and assessor-blind study performed in workers of the main Volkswagen factory (Wolfsburg, Germany). Volunteers with diagnosed MetS were randomly assigned (1:1) to a 6-month lifestyle intervention focusing on supervised, activity-tracker-guided exercise or to a waiting-list control group. This secondary analysis assessed the effect of the intervention on liver enzymes and MAFLD-related parameters.RESULTS:We screened 543 individuals between October 10, 2017, and February 27, 2018, of whom 314 were randomly assigned to the intervention group (n = 160) or control group (n = 154). Liver transaminases, alkaline phosphatase, and gamma-glutamyl transferase significantly decreased after 6 months in the intervention group compared with the CG. Furthermore, an aspartate aminotransferase-to-platelet ratio index score as a marker for liver fibrosis significantly decreased in the intervention group. These improvements were associated with changes in obesity and exercise capacity.DISCUSSION:A 6-month lifestyle intervention based on exercise training with individualized telemonitoring-based supervision led to improvements of liver inflammation and fibrosis in employees with MetS. Therefore, this intervention shows therapeutic potential for individuals at high risk of MAFLD (ClinicalTrials.gov Identifier: NCT03293264).

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Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis - [published Version]

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