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Vogt, Julia C. [Verfasser:in]; Brandes, Gudrun [Verfasser:in]; Ehlert, Nina [Verfasser:in]; Behrens, Peter [Verfasser:in]; Nolte, Ingo [Verfasser:in]; Mueller, Peter P. [Verfasser:in]; Lenarz, Thomas [Verfasser:in]; Stieve, Martin [Verfasser:in]

Free Bioverit® II implants coated with a nanoporous silica layer in a mouse ear model - A histological study - [published Version]

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  • Medientyp: Sonstige Veröffentlichung; E-Artikel
  • Titel: Free Bioverit® II implants coated with a nanoporous silica layer in a mouse ear model - A histological study
  • Beteiligte: Vogt, Julia C. [Verfasser:in]; Brandes, Gudrun [Verfasser:in]; Ehlert, Nina [Verfasser:in]; Behrens, Peter [Verfasser:in]; Nolte, Ingo [Verfasser:in]; Mueller, Peter P. [Verfasser:in]; Lenarz, Thomas [Verfasser:in]; Stieve, Martin [Verfasser:in]
  • Erschienen: London : SAGE Publications Ltd., 2009
  • Erschienen in: Journal of Biomaterials Applications 24 (2009), Nr. 2
  • Ausgabe: published Version
  • Sprache: Englisch
  • DOI: https://doi.org/10.15488/3009; https://doi.org/10.1177/0885328208095469
  • ISSN: 0885-3282
  • Schlagwörter: time ; Silica-nanocoating ; rabbit ; ultrastructure ; Mouse models ; nanomaterial ; Histology ; Materials testing ; transplantation ; porosity ; Replacement materials ; animal model ; Bioverit® II ; Biological radiation effects ; Inflammatory cells ; bone development ; middle ear prosthesis ; Middle ears ; Gene expression ; Biocompatibility ; bioglass ; Bio-glass ; Musculoskeletal system ; silicon dioxide ; [...]
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  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: The objective of this study is to evaluate the suitability of a mouse middle ear model for testing ossicular replacement materials. Twenty-four BALB/c mice are implanted with the bioglass-ceramic Bioverit® II which is coated with a silica-nanostructure or with plain Bioverit® II as a control. After 2, 6, and 12 weeks, 4 mice per group are sacrificed and both complete petrous bones are analyzed histologically. All implants revealed in situ an incipient growth of thin connective tissue layers over the surface, followed by a spreading of epithelial cells. The osseogenic response which is increasing with time is more intense in the coated Bioverit® II specimens. The absence of inflammatory cells suggests an excellent biocompatibility of the silica nano structure. As the results are comparable to a study with the same materials in rabbits, the mouse model described is highly suitable for evaluation of new ossicular replacement materials. Additionally, by gene expression analysis a more detailed insight into cellular interactions of the middle ear is offered.
  • Zugangsstatus: Freier Zugang