In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

Medientyp: Sonstige Veröffentlichung; E-Artikel

Titel: In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties

Beteiligte: Janßen, Hilke Catherina [Verfasser:in]; Dahlhaus, David [Verfasser:in]; Warwas, Dawid Peter [Verfasser:in]; Meißner, Jessic [Verfasser:in]; Taptimthong, Piriya [Verfasser:in]; Kietzmann, Manfred [Verfasser:in]; Behrens, Pete [Verfasser:in]; Reifenrath, Janin [Verfasser:in]; Angrisani, Nina [Verfasser:in]

Erschienen: Berlin : Springer Nature, 2018

Ausgabe: published Version

Sprache: Englisch

DOI: https://doi.org/10.15488/4735; https://doi.org/10.1186/s12951-018-0422-6

ISSN: 1477-3155

Schlagwörter: Biocompatibility ; PEGylation ; Ferritic steel ; Core–shell nanoparticles ; Martensitic steel ; Nanoporous silica ; Mouse model ; Nanobiotechnology ; Drug targeting ; Superparamagnetic Fe3O4

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Beschreibung: Background: In orthopedic surgery, implant-associated infections are still a major problem. For the improvement of the selective therapy in the infection area, magnetic nanoparticles as drug carriers are promising when used in com- bination with magnetizable implants and an externally applied magnetic field. These implants principally increase the strength of the magnetic field resulting in an enhanced accumulation of the drug loaded particles in the target area and therewith a reduction of the needed amount and the risk of undesirable side effects. In the present study magnetic nanoporous silica core–shell nanoparticles, modified with fluorophores (fluorescein isothiocyanate/FITC or rhodamine B isothiocyanate/RITC) and poly(ethylene glycol) (PEG), were used in combination with metallic plates of different magnetic properties and with a magnetic field. In vitro and in vivo experiments were performed to investi- gate particle accumulation and retention and their biocompatibility. Results: Spherical magnetic silica core–shell nanoparticles with reproducible superparamagnetic behavior and high porosity were synthesized. Based on in vitro proliferation and viability tests the modification with organic fluorophores and PEG led to highly biocompatible fluorescent particles, and good dispersibility. In a circular tube system martensi- tic steel 1.4112 showed superior accumulation and retention of the magnetic particles in comparison to ferritic steel 1.4521 and a Ti90Al6V4 control. In vivo tests in a mouse model where the nanoparticles were injected subcutaneously showed the good biocompatibility of the magnetic silica nanoparticles and their accumulation on the surface of a metallic plate, which had been implanted before, and in the surrounding tissue. Conclusion: With their superparamagnetic properties and their high porosity, multifunctional magnetic nanoporous silica nanoparticles are ideal candidates as drug carriers. In combination with their good biocompatibility in vitro, they have ideal properties for an ...

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In vitro and in vivo accumulation of magnetic nanoporous silica nanoparticles on implant materials with different magnetic properties - [published Version]

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