> Detailanzeige

Philippe, Marc [VerfasserIn]; Gatterer, Hannes [VerfasserIn]; Burtscher, Martin [VerfasserIn]; Weinberger, Birgit [VerfasserIn]; Keller, Michael [VerfasserIn]; Grubeck-Loebenstein, Beatrix [VerfasserIn]; Fleckenstein, Johannes [VerfasserIn]; Alack, Katharina [VerfasserIn]; Krüger, Karsten [VerfasserIn]

Concentric and eccentric endurance exercise reverse hallmarks of T-Cell senescence in pre-diabetic subjects - [published Version]

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel; Sonstige Veröffentlichung
  • Titel: Concentric and eccentric endurance exercise reverse hallmarks of T-Cell senescence in pre-diabetic subjects
  • Beteiligte: Philippe, Marc [VerfasserIn]; Gatterer, Hannes [VerfasserIn]; Burtscher, Martin [VerfasserIn]; Weinberger, Birgit [VerfasserIn]; Keller, Michael [VerfasserIn]; Grubeck-Loebenstein, Beatrix [VerfasserIn]; Fleckenstein, Johannes [VerfasserIn]; Alack, Katharina [VerfasserIn]; Krüger, Karsten [VerfasserIn]
  • Erschienen: Lausanne : Frontiers Media S.A., 2019
  • Erschienen in: Frontiers in Physiology 10 (2019)
  • Ausgabe: published Version
  • Sprache: Englisch
  • DOI: https://doi.org/10.15488/5222; https://doi.org/10.3389/fphys.2019.00684
  • ISSN: 1664-042X
  • Schlagwörter: Concentric exercise ; Eccentric exercise ; Naïve T-cells ; TEMRA cells ; Inflammation
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or eccentric endurance exercise training on the composition of the T-cell compartment in pre-diabetic subjects. Sixteen male older adults with impaired glucose tolerance were recruited and performed either concentric exercise (CE) or eccentric exercise (EE) walking 3 times a week for 3 weeks. Fasting venous blood sampling was performed before training and after the training intervention. Various T-cell subpopulations were analyzed by flow cytometry. We did not find significant time × group effects (interaction) but found several significant time effects for cell type ratios and cell subsets proportions. There was an increase of the CD4+/CD8+ (0.55 ± 0.85%; p = 0.033) and CD4+/CD3+ ratio (5.63 ± 8.44%; p = 0.018) and a decrease of the CD8+/CD3+ ratio (-0.95 ± 1.64%; p = 0.049) after training. We found proportional increases of CD4+/CCR7+/CD45RO+ central memory cells (5.02 ± 7.68%; p = 0.030), naïve CD8+/CCR7+/CD45RO- (3.00 ± 6.68%; p = 0.047) and CD8+/CCR7+/CD45RO+ central memory cells (3.01 ± 3.70%; p = 0.009), while proportions of CD4+/CCR7-/CD45RO- TEMRA cells (-2.17 ± 4.66%; p = 0.012), CD8+/CCR7-/CD45RO- TEMRA cells (-5.11 ± 7.02%; p = 0.018) and CD16+ cells (-4.67 ± 6.45%; p = 0.016) decreased after training. 3 weeks of either CE or EE were effective in reversing hallmarks of T-cell senescence in pre-diabetic subjects. It is suggested that exercise stimulates production and mobilization of naïve T-cells, while differentiated TEMRA cells might disappear by apoptosis.
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)