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Brangsch, J. [VerfasserIn]; Reimann, C. [VerfasserIn]; Kaufmann, Jan Ole [VerfasserIn]; Adams, L. C. [VerfasserIn]; Onthank, D. [VerfasserIn]; Thöne-Reineke, C. [VerfasserIn]; Robinson, S. [VerfasserIn]; Wilke, Marco [VerfasserIn]; Weller, Michael G. [VerfasserIn]; Buchholz, R. [VerfasserIn]; Karst, U. [VerfasserIn]; Botnar, R. [VerfasserIn]; Hamm, B. [VerfasserIn]; Makowski, M. R. [VerfasserIn]

Molecular MR-Imaging for Noninvasive Quantification of the Anti-Inflammatory Effect of Targeting Interleukin-1β in a Mouse Model of Aortic Aneurysm

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  • Medientyp: E-Artikel
  • Titel: Molecular MR-Imaging for Noninvasive Quantification of the Anti-Inflammatory Effect of Targeting Interleukin-1β in a Mouse Model of Aortic Aneurysm
  • Beteiligte: Brangsch, J. [VerfasserIn]; Reimann, C. [VerfasserIn]; Kaufmann, Jan Ole [VerfasserIn]; Adams, L. C. [VerfasserIn]; Onthank, D. [VerfasserIn]; Thöne-Reineke, C. [VerfasserIn]; Robinson, S. [VerfasserIn]; Wilke, Marco [VerfasserIn]; Weller, Michael G. [VerfasserIn]; Buchholz, R. [VerfasserIn]; Karst, U. [VerfasserIn]; Botnar, R. [VerfasserIn]; Hamm, B. [VerfasserIn]; Makowski, M. R. [VerfasserIn]
  • Erschienen: BAM-Publica - Publikationsserver der Bundesanstalt für Materialforschung und -prüfung (BAM), 2020
  • Sprache: Englisch
  • DOI: https://doi.org/10.1177/1536012120961875
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: Background: Molecular-MRI is a promising imaging modality for the assessment of abdominal aortic aneurysms (AAAs). Interleukin-1β (IL-1β) represents a new therapeutic tool for AAA-treatment, since pro-inflammatory cytokines are key-mediators of inflammation. This study investigates the potential of molecular-MRI to evaluate therapeutic effects of an anti-IL-1β-therapy on AAA-formation in a mouse-model. Methods: Osmotic-minipumps were implanted in apolipoprotein-deficient-mice (N = 27). One group (Ang-II+01BSUR group, n = 9) was infused with angiotensin-II (Ang-II) for 4 weeks and received an anti-murine IL-1β-antibody (01BSUR) 3 times. One group (Ang-II-group, n = 9) was infused with Ang-II for 4 weeks but received no treatment. Control-group (n = 9) was infused with saline and received no treatment. MR-imaging was performed using an elastin-specific gadolinium-based-probe (0.2 mmol/kg). Results: Mice of the Ang-II+01BSUR-group showed a lower aortic-diameter compared to mice of the Ang-II-group and control mice (p < 0.05). Using the elastin-specific-probe, a significant decrease in elastin-destruction was observed in mice of the Ang-II+01BSUR-group. In vivo MR-measurements correlated well with histopathology (y = 0.34x-13.81, R2 = 0.84, p < 0.05), ICP-MS (y = 0.02x+2.39; R2 = 0.81, p < 0.05) and LA-ICP-MS. Immunofluorescence and western-blotting confirmed a reduced IL-1β-expression. Conclusions: Molecular-MRI enables the early visualization and quantification of the anti-inflammatory-effects of an IL-1β-inhibitor in a mouse-model of AAAs. Responders and non-responders could be identified early after the initiation of the therapy using molecular-MRI.
  • Zugangsstatus: Freier Zugang