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In the Asymmetric Traveling Salesperson Problem (ATSP) the goal is to find a closed walk of minimum cost in a directed graph visiting every vertex. We consider the approximability of ATSP on topologically restricted graphs. It has been shown by Oveis Gharan and Saberi [SODA, 2011] that there exists polynomial-time constant-factor approximations on planar graphs and more generally graphs of constant orientable genus. This result was extended to non-orientable genus by Erickson and Sidiropoulos [SoCG, 2014]. We show that for any class of nearly-embeddable graphs, ATSP admits a polynomial-time constant-factor approximation. More precisely, we show that for any fixed non-negative k, there exist positive alpha and beta, such that ATSP on n-vertex k-nearly-embeddable graphs admits an alpha-approximation in time O(n^beta). The class of k-nearly-embeddable graphs contains graphs with at most k apices, k vortices of width at most k, and an underlying surface of either orientable or non-orientable genus at most k. Prior to our work, even the case of graphs with a single apex was open. Our algorithm combines tools from rounding the Held-Karp LP via thin trees with dynamic programming. We complement our upper bounds by showing that solving ATSP exactly on graphs of pathwidth k (and hence on k-nearly embeddable graphs) requires time n^{Omega(k)}, assuming the Exponential-Time Hypothesis (ETH). This is surprising in light of the fact that both TSP on undirected graphs and Minimum Cost Hamiltonian Cycle on directed graphs are FPT parameterized by treewidth.