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Strelow, Joshua N. [Verfasser:in]; Dembek, Till A. [Verfasser:in]; Baldermann, Juan C. [Verfasser:in]; Andrade, Pablo [Verfasser:in]; Fink, Gereon R. [Verfasser:in]; Visser-Vandewalle, Veerle [Verfasser:in]; Barbe, Michael T. [Verfasser:in]

Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease

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  • Medientyp: E-Artikel
  • Titel: Low beta-band suppression as a tool for DBS contact selection for akinetic-rigid symptoms in Parkinson's disease
  • Beteiligte: Strelow, Joshua N. [Verfasser:in]; Dembek, Till A. [Verfasser:in]; Baldermann, Juan C. [Verfasser:in]; Andrade, Pablo [Verfasser:in]; Fink, Gereon R. [Verfasser:in]; Visser-Vandewalle, Veerle [Verfasser:in]; Barbe, Michael T. [Verfasser:in]
  • Erschienen: Elsevier Science, 2023
  • Erschienen in: Parkinsonism & related disorders 112, 105478 - (2023). doi:10.1016/j.parkreldis.2023.105478
  • Sprache: Englisch
  • DOI: https://doi.org/10.1016/j.parkreldis.2023.105478; https://doi.org/10.34734/FZJ-2023-02378
  • ISSN: 1353-8020; 1873-5126
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: AbstractBackground: Suppression of pathologically altered activity in the beta-band has previously been suggested as a biomarker for feedback-based neurostimulation in subthalamic deep brain stimulation (STN-DBS) for Parkinson's Disease (PD).Objective: To assess the utility of beta-band suppression as a tool for contact selection in STN-DBS for PD.Methods: A sample of seven PD patients (13 hemispheres) with newly implanted directional DBS leads of the STN were recorded during a standardized monopolar contact review (MPR). Recordings were received from contact pairs adjacent to the stimulation contact. The degree of beta-band suppression for each investigated contact was then correlated to the respective clinical results. Additionally, we have implemented a cumulative ROC analysis, to test the predictive value of beta-band suppression on the clinical efficacy of the respective contacts.Results: Stimulation ramping led to frequency-specific changes in the beta-band, while lower frequencies remained unaffected. Most importantly, our results showed that the degree of low beta-band suppression from baseline activity (stimulation off) served as a predictor for clinical efficacy of the respective stimulation contact. In contrast suppression of high beta-band activity yielded no predictive power.Conclusion: The degree of low beta-band suppression can serve as a time-saving, objective tool for contact selection in STN-DBS.Keywords: DBS programming; Deep brain stimulation (DBS); Local field potential (LFP); Nucleus subthalamicus (STN).
  • Zugangsstatus: Freier Zugang