Erschienen in:Jülich : Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag, Schriften des Forschungszentrums Jülich. Reihe Lebenswissenschaften/Life Sciences 41, 96, XXVI S. (2007). = Universität Oldenburg, Diss., 2007
Sprache:
Deutsch
ISBN:
3-89336-504-4
ISSN:
1433-5549
Entstehung:
Anmerkungen:
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Beschreibung:
In the PhD thesis at hand neurobiological correlates of the regulation of affect in children and adolescents with conduct disorder (CD) and attention deficit-/hyperactivity disorder (ADHD) were investigated by using neuroscientific rnethods. These children and adolescents tend to show high levels of aggressive and antisocial behaviour (for Review see Barrickman 2003). Disruptive behaviour disorders are the most frequent (30-50%) diagnoses in child psychiatric services (Schmeck & Poustka 2000). Furthermore, the prognosis for children with an "early-onset" of this disorder is very poor. Most children and adolescents with CD show a remission of the symptomatology within adolescence (Moffitt et al. 2002). But the risk for developing an antisocial personality disorder (ASPD) is twice as high in children showing an "early-onset " of CD (Robins 1991). About 10% of these children even develop an ASPD (Herpertz & Sass 2000). Latest research indicates that over the last two decades the prevalence of CD has risen, specifically within the urban population (Lahey et al. 1999 ; Tcheremissine & Lieving 2006). Furthermore, children with CD have a high risk of developing cornorbid disorders. Especially ADHD is often associated with CD. The experiments carried out for this thesis showed that approximately three quarters of all children with CD also had a cornorbid ADHD. Affective and fear disorders as well as substance abuse are frequent, too (Vloet et al. 2006). CD is caused by heterogencous factors. There seems to be a greater load of biological risk factors in the early-starter subtype. This fact is important, because biological factors shape children's early development. Today, neuroimaging techniques like Magnet- Resonance-Irnaging (MRI) provide a unique chance of investigating structural and functional differences that are associated with neuropsychiatric disorders in childhood. However, antisocial behaviour is notably less studied in childhood and adolescence than in adulthood. To date, there are only few ...