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Bittner, Nora [VerfasserIn]; Jockwitz, Christiane [VerfasserIn]; Caspers, Svenja [VerfasserIn]; Mühleisen, Thomas W. [VerfasserIn]; Hoffstaedter, Felix [VerfasserIn]; Eickhoff, Simon [VerfasserIn]; Moebus, Susanne [VerfasserIn]; Bayen, Ute J. [VerfasserIn]; Cichon, Sven [VerfasserIn]; Zilles, Karl [VerfasserIn]; Amunts, Katrin [VerfasserIn]

Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults

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  • Medientyp: E-Artikel
  • Titel: Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults
  • Beteiligte: Bittner, Nora [VerfasserIn]; Jockwitz, Christiane [VerfasserIn]; Caspers, Svenja [VerfasserIn]; Mühleisen, Thomas W. [VerfasserIn]; Hoffstaedter, Felix [VerfasserIn]; Eickhoff, Simon [VerfasserIn]; Moebus, Susanne [VerfasserIn]; Bayen, Ute J. [VerfasserIn]; Cichon, Sven [VerfasserIn]; Zilles, Karl [VerfasserIn]; Amunts, Katrin [VerfasserIn]
  • Erschienen: Nature Publishing Group UK, 2019
  • Erschienen in: Nature Communications 10(1), 621 (2019). doi:10.1038/s41467-019-08500-x
  • Sprache: Englisch
  • DOI: https://doi.org/10.1038/s41467-019-08500-x
  • ISSN: 2041-1723
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: Lifestyle contributes to inter-individual variability in brain aging, but previous studies focusedon the effects of single lifestyle variables. Here, we studied the combined and individualcontributions of four lifestyle variables - alcohol consumption, smoking, physical activity,and social integration - to brain structure and functional connectivity in a population-basedcohort of 549 older adults. A combined lifestyle risk score was associated with decreasedgyrification in left premotor and right prefrontal cortex, and higher functional connectivityto sensorimotor and prefrontal cortex. While structural differences were driven by alcoholconsumption, physical activity, and social integration, higher functional connectivity wasdriven by smoking. Results suggest that combining differentially contributing lifestylevariables may be more than the sum of its parts. Associations generally were neither alteredby adjustment for genetic risk, nor by depressive symptomatology or education, underliningthe relevance of daily habits for brain health.
  • Zugangsstatus: Freier Zugang