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Raschle, Nora Maria [VerfasserIn]; Menks, Willeke Martine [VerfasserIn]; Bernhard, Anka [VerfasserIn]; Konrad, Kerstin [VerfasserIn]; Herpertz-Dahlmann, Beate [VerfasserIn]; Freitag, Christine M. [VerfasserIn]; Fairchild, Graeme [VerfasserIn]; De Brito, Stephane A. [VerfasserIn]; Stadler, Christina [VerfasserIn]; Fehlbaum, Lynn Valérie [VerfasserIn]; Steppan, Martin [VerfasserIn]; Smaragdi, Areti [VerfasserIn]; Gonzalez-Madruga, Karen [VerfasserIn]; Rogers, Jack [VerfasserIn]; Clanton, Roberta [VerfasserIn]; Kohls, Gregor [VerfasserIn]; Martinelli, Anne [VerfasserIn]

Callous-unemotional traits and brain structure: Sex-specific effects in anterior insula of typically-developing youths

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  • Medientyp: E-Artikel
  • Titel: Callous-unemotional traits and brain structure: Sex-specific effects in anterior insula of typically-developing youths
  • Beteiligte: Raschle, Nora Maria [VerfasserIn]; Menks, Willeke Martine [VerfasserIn]; Bernhard, Anka [VerfasserIn]; Konrad, Kerstin [VerfasserIn]; Herpertz-Dahlmann, Beate [VerfasserIn]; Freitag, Christine M. [VerfasserIn]; Fairchild, Graeme [VerfasserIn]; De Brito, Stephane A. [VerfasserIn]; Stadler, Christina [VerfasserIn]; Fehlbaum, Lynn Valérie [VerfasserIn]; Steppan, Martin [VerfasserIn]; Smaragdi, Areti [VerfasserIn]; Gonzalez-Madruga, Karen [VerfasserIn]; Rogers, Jack [VerfasserIn]; Clanton, Roberta [VerfasserIn]; Kohls, Gregor [VerfasserIn]; Martinelli, Anne [VerfasserIn]
  • Erschienen: Elsevier, 2018
  • Erschienen in: NeuroImage: Clinical 17, 856 - 864 (2018). doi:10.1016/j.nicl.2017.12.015
  • Sprache: Englisch
  • DOI: https://doi.org/10.1016/j.nicl.2017.12.015
  • ISSN: 2213-1582
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: Callous-unemotional traits are characterized by a lack of empathy, a disregard for others' feelings and shallow or deficient affect, such as a lack of remorse or guilt. Neuroanatomical correlates of callous-unemotional traits have been demonstrated in clinical samples (i.e., adolescents with disruptive behavior disorders). However, it is unknown whether callous-unemotional traits are associated with neuroanatomical correlates within normative populations without clinical levels of aggression or antisocial behavior. Here we investigated the relationship between callous-unemotional traits and gray matter volume using voxel-based morphometry in a large sample of typically-developing boys and girls (N = 189). Whole-brain multiple regression analyses controlling for site, total intracranial volume, and age were conducted in the whole sample and in boys and girls individually. Results revealed that sex and callous-unemotional traits interacted to predict gray matter volume when considering the whole sample. This interaction was driven by a significant positive correlation between callous-unemotional traits and bilateral anterior insula volume in boys, but not girls. Insula gray matter volume explained 19% of the variance in callous-unemotional traits for boys. Our results demonstrate that callous-unemotional traits are related to variations in brain structure beyond psychiatric samples. This association was observed for boys only, underlining the importance of considering sex as a factor in future research designs. Future longitudinal studies should determine whether these findings hold over childhood and adolescence, and whether the neuroanatomical correlates of callous-unemotional traits are predictive of future psychiatric vulnerability.
  • Zugangsstatus: Freier Zugang