Investigation of Cerebral O-(2-[$^{18}$F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models

Medientyp: E-Artikel

Titel: Investigation of Cerebral O-(2-[$^{18}$F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models

Beteiligte: Stegmayr, Carina [Verfasser:in]; Surges, Rainer [Verfasser:in]; Mottaghy, Felix M. [Verfasser:in]; Langen, Karl-Josef [Verfasser:in]; Choi, Chang-Hoon [Verfasser:in]; Burda, Nicole [Verfasser:in]; Stoffels, Gabriele [Verfasser:in]; Filß, Christian [Verfasser:in]; Willuweit, Antje [Verfasser:in]; Neumaier, Bernd [Verfasser:in]; Heinzel, Alexander [Verfasser:in]; Shah, N. Jon [Verfasser:in]

Erschienen: Springer, 2020

Sprache: Englisch

DOI: https://doi.org/10.1007/s11307-020-01503-x

ISSN: 1860-2002; 1536-1632

Entstehung:

Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.

Beschreibung: A recent study reported on high, longer lasting and finally reversible cerebral uptake of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) induced by epileptic activity. Therefore, we examined cerebral [18F]FET uptake in two chemically induced rat epilepsy models and in patients with focal epilepsy to further investigate whether this phenomenon represents a major pitfall in brain tumor diagnostics and whether [18F]FET may be a potential marker to localize epileptic foci.Five rats underwent kainic acid titration to exhibit 3 to 3.5 h of class IV–V motor seizures (status epilepticus, SE). Rats underwent 4× [18F]FET PET and 4× MRI on the following 25 days. Six rats underwent kindling with pentylenetetrazol (PTZ) 3 to 8×/week over 10 weeks, and hence, seizures increased from class I to class IV. [18F]FET PET and MRI were performed regularly on days with and without seizures. Four rats served as healthy controls. Additionally, five patients with focal epilepsy underwent [18F]FET PET within 12 days after the last documented seizure.No abnormalities in [18F]FET PET or MRI were detected in the kindling model. The SE model showed significantly decreased [18F]FET uptake 3 days after SE in all examined brain regions, and especially in the amygdala region, which normalized within 2 weeks. Corresponding signal alterations in T2-weighted MRI were noted in the amygdala and hippocampus, which recovered 24 days post-SE. No abnormality of cerebral [18F]FET uptake was noted in the epilepsy patients.There was no evidence for increased cerebral [18F]FET uptake after epileptic seizures neither in the rat models nor in patients. The SE model even showed decreased [18F]FET uptake throughout the brain. We conclude that epileptic seizures per se do not cause a longer lasting increased [18F]FET accumulation and are unlikely to be a major cause of pitfall for brain tumor diagnostics.

Zugangsstatus: Freier Zugang

Nur in Feld suchen:

Zuletzt gesuchte Begriffe: