> Detailanzeige

Eickhoff, Roman Marius [VerfasserIn]; Kroh, Andreas [VerfasserIn]; Eickhoff, Simon [VerfasserIn]; Heise, Daniel [VerfasserIn]; Helmedag, Marius Julian [VerfasserIn]; Tolba, Rene H [VerfasserIn]; Klinge, Uwe [VerfasserIn]; Neumann, Ulf Peter [VerfasserIn]; Klink, Christian Daniel [VerfasserIn]; Lambertz, Andreas [VerfasserIn]

A peritoneal defect covered by intraperitoneal mesh prosthesis effects an increased and distinctive foreign body reaction in a minipig model

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: A peritoneal defect covered by intraperitoneal mesh prosthesis effects an increased and distinctive foreign body reaction in a minipig model
  • Beteiligte: Eickhoff, Roman Marius [VerfasserIn]; Kroh, Andreas [VerfasserIn]; Eickhoff, Simon [VerfasserIn]; Heise, Daniel [VerfasserIn]; Helmedag, Marius Julian [VerfasserIn]; Tolba, Rene H [VerfasserIn]; Klinge, Uwe [VerfasserIn]; Neumann, Ulf Peter [VerfasserIn]; Klink, Christian Daniel [VerfasserIn]; Lambertz, Andreas [VerfasserIn]
  • Erschienen: Sage, 2020
  • Erschienen in: Journal of biomaterials applications 35(6), 732-739 (2020). doi:10.1177/0885328220963918
  • Sprache: Englisch
  • DOI: https://doi.org/10.1177/0885328220963918
  • ISSN: 1530-8022; 0885-3282
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: Background: The incidence of incisional hernia is with up to 30% one of the frequent long-term complication afterlaparotomy. After establishing minimal invasive operations, the laparoscopic intraperitoneal onlay mesh technique(lap. IPOM) was first described in 1993. Little is known about the foreign body reaction of IPOM-meshes, which covereda defect of the parietal peritoneum. This is becoming more important, since IPOM procedure with peritoneal-sacresection and hernia port closing (IPOM plus) is more frequently used.Methods: In 18 female minipigs, two out of three Polyvinylidene-fluoride (PVDF) -meshes (I: standard IPOM; II: IPOMwith modified structure [bigger pores]; III: IPOM with the same structure as IPOM IIþdegradable hydrogel-coating)were placed in a laparoscopic IPOM procedure. Before mesh placement, a 2x2cm peritoneal defect was created. After30 days, animals were euthanized, adhesions were evaluated by re-laparoscopy and mesh samples were explanted forhistological and immunohistochemichal investigations.Results: All animals recovered after implantation and had no complications during the follow-up period. Analysingforeign body reaction, the IPOM II mesh had a significant smaller inner granuloma, compared to the other meshes (IPOMII: 8.4 mm1.3 vs. IPOM I 9.1 mm1.3, p<0.001). The degradable hydrogel coating does not prevent adhesionsmeasured by Diamond score (p¼0.46). A peritoneal defect covered by a standard or modified IPOM mesh was asignificant factor for increasing foreign body granuloma, the amount of CD3þ lymphocytes, CD68þ macrophages anddecrease of pore size.Conclusion: A peritoneal defect covered by IPOM prostheses leads to an increased foreign body reaction compared tointact peritoneum. Whenever feasible, a peritoneal defect should be closed accurately before placing an IPOM-mesh toavoid an excessive foreign body reaction and therefore inferior biomaterial properties of the prosthesis.
  • Zugangsstatus: Freier Zugang