> Detailanzeige

Farrell, Michelle E. [VerfasserIn]; Kennedy, Kristen M. [VerfasserIn]; Rodrigue, Karen M. [VerfasserIn]; Wig, Gagan [VerfasserIn]; Bischof, Gérard N. [VerfasserIn]; Rieck, Jennifer R. [VerfasserIn]; Chen, Xi [VerfasserIn]; Festini, Sara B. [VerfasserIn]; Devous, Michael D. [VerfasserIn]; Park, Denise C. [VerfasserIn]

Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults
  • Beteiligte: Farrell, Michelle E. [VerfasserIn]; Kennedy, Kristen M. [VerfasserIn]; Rodrigue, Karen M. [VerfasserIn]; Wig, Gagan [VerfasserIn]; Bischof, Gérard N. [VerfasserIn]; Rieck, Jennifer R. [VerfasserIn]; Chen, Xi [VerfasserIn]; Festini, Sara B. [VerfasserIn]; Devous, Michael D. [VerfasserIn]; Park, Denise C. [VerfasserIn]
  • Erschienen: American Medical Association, 2017
  • Erschienen in: JAMA neurology 74(7), 830 - 838 (2017). doi:10.1001/jamaneurol.2017.0892
  • Sprache: Englisch
  • DOI: https://doi.org/10.1001/jamaneurol.2017.0892
  • ISSN: 0003-9942; 2168-6157; 1538-3687; 2168-6149; 0375-8540
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: Importance Presently, the clinical standard for reporting the results of an amyloid positron emission tomography scan is to assign a dichotomous rating of positive or negative for the presence of amyloid. In a 4-year longitudinal study, we investigated whether using a continuous measure of the magnitude of baseline amyloid burden would provide valuable information about the rate of future cognitive decline over the subsequent 4 years compared with a dichotomous measure in middle-aged and older adults.Objective To examine whether a continuous, dose-response relationship between amyloid burden and cognitive decline was present among middle-aged and older adults.Design, Setting, and Participants This cohort study included 174 participants from the Dallas Lifespan Brain Study who were 40 to 89 years old at the beginning of the study, were cognitively normal at baseline (a Mini-Mental State Examination score of 26 or higher) with no history of neurological or psychiatric disorders, and had completed amyloid imaging ([18F]-florbetapir) at baseline and cognitive assessments at baseline and a 4-year follow-up. Continuous amyloid burden was measured as the mean cortical standardized uptake value ratio (SUVR) at baseline.Main Outcomes and Measures Linear mixed models assessed the effect of increasing baseline amyloid over time (SUVR × time interaction) on episodic memory, reasoning, processing speed, vocabulary, and Mini-Mental State Examination performance. Age, sex, education, apolipoprotein ε4, and the random effect of intercepts were included as covariates.Results The mean (SD) age for all participants (n = 174) was 66.44 (11.74) years, and 65 participants (37%) were men. The primary analyses yielded significant SUVR × time interactions in episodic memory, processing speed, vocabulary, and Mini-Mental State Examination performance, but not in reasoning performance. Higher baseline SUVR projected greater cognitive decline over 4 years. When controlling for variance related to a dichotomized positive/negative ...
  • Zugangsstatus: Freier Zugang