> Detailanzeige

Kernbach, Julius M [Verfasser:in]; Delev, Daniel [Verfasser:in]; Serra, Carlo [Verfasser:in]; Krayenbühl, Niklaus [Verfasser:in]; Akeret, Kevin [Verfasser:in]; Neuloh, Georg [Verfasser:in]; Clusmann, Hans [Verfasser:in]; Bzdok, Danilo [Verfasser:in]; Eickhoff, Simon B [Verfasser:in]; Staartjes, Victor E [Verfasser:in]; Vasella, Flavio [Verfasser:in]; Weller, Michael [Verfasser:in]; Regli, Luca [Verfasser:in]

Meta-topologies define distinct anatomical classes of brain tumours linked to histology and survival

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Meta-topologies define distinct anatomical classes of brain tumours linked to histology and survival
  • Beteiligte: Kernbach, Julius M [Verfasser:in]; Delev, Daniel [Verfasser:in]; Serra, Carlo [Verfasser:in]; Krayenbühl, Niklaus [Verfasser:in]; Akeret, Kevin [Verfasser:in]; Neuloh, Georg [Verfasser:in]; Clusmann, Hans [Verfasser:in]; Bzdok, Danilo [Verfasser:in]; Eickhoff, Simon B [Verfasser:in]; Staartjes, Victor E [Verfasser:in]; Vasella, Flavio [Verfasser:in]; Weller, Michael [Verfasser:in]; Regli, Luca [Verfasser:in]
  • Erschienen: Guarantors of Brain, 2023
  • Erschienen in: Brain communications 5(1), fcac336 (2023). doi:10.1093/braincomms/fcac336
  • Sprache: Englisch
  • DOI: https://doi.org/10.1093/braincomms/fcac336
  • ISSN: 2632-1297
  • Entstehung:
  • Anmerkungen: Diese Datenquelle enthält auch Bestandsnachweise, die nicht zu einem Volltext führen.
  • Beschreibung: The current World Health Organization classification integrates histological and molecular features of brain tumours. The aim of this study was to identify generalizable topological patterns with the potential to add an anatomical dimension to the classification of brain tumours. We applied non-negative matrix factorization as an unsupervised pattern discovery strategy to the fine-grained topographic tumour profiles of 936 patients with neuroepithelial tumours and brain metastases. From the anatomical features alone, this machine learning algorithm enabled the extraction of latent topological tumour patterns, termed meta-topologies. The optimal part-based representation was automatically determined in 10 000 split-half iterations. We further characterized each meta-topology's unique histopathologic profile and survival probability, thus linking important biological and clinical information to the underlying anatomical patterns. In neuroepithelial tumours, six meta-topologies were extracted, each detailing a transpallial pattern with distinct parenchymal and ventricular compositions. We identified one infratentorial, one allopallial, three neopallial (parieto-occipital, frontal, temporal) and one unisegmental meta-topology. Each meta-topology mapped to distinct histopathologic and molecular profiles. The unisegmental meta-topology showed the strongest anatomical-clinical link demonstrating a survival advantage in histologically identical tumours. Brain metastases separated to an infra- and supratentorial meta-topology with anatomical patterns highlighting their affinity to the cortico-subcortical boundary of arterial watershed areas.Using a novel data-driven approach, we identified generalizable topological patterns in both neuroepithelial tumours and brain metastases. Differences in the histopathologic profiles and prognosis of these anatomical tumour classes provide insights into the heterogeneity of tumour biology and might add to personalized clinical decision-making.
  • Zugangsstatus: Freier Zugang