Völker, Linus
[VerfasserIn]
;
Benzing, Thomas
[AkademischeR BetreuerIn]
Analyse der Expression von Nephrin und Neph-Proteinen und eine mögliche Bedeutung neuronaler Proteine bei der Entwicklung des glomerulären Filters der Niere
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Medientyp:
E-Book;
Hochschulschrift
Titel:
Analyse der Expression von Nephrin und Neph-Proteinen und eine mögliche Bedeutung neuronaler Proteine bei der Entwicklung des glomerulären Filters der Niere
Beschreibung:
Zusammenfassung: The podocyte plays a key role in maintaining the filtration capacity of the kidney. The slit diaphragm, an essential component of the three-layered glomerular filtration unit, spans the gap between the intricate foot processes of the cell. Damage to the podocyte leads to foot process effacement and proteinuria. Factors and signaling pathways involved in the maintenance of the podocyte cytoarchitecture and the slit diaphragm, however, still remain elusive. In view of the fact that podocytes and neurons share many features, the expression of podocyte proteins Nephrin, Neph1, Neph2, and Neph3 was analyzed by In Situ hybridization on adult and embryonic neural tissues. Moreover, array analysis revealed known neuronal proteins that are involved in such diverse processes as neuronal migration, synaptic plasticity, and axonal guidance to also be expressed in podocytes. These results could further be confirmed by In Situ hybridization analysis and functional assays.