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Händel, Chris [VerfasserIn]; Schmidt, B.U. Sebastian [VerfasserIn]; Schiller, Jürgen [VerfasserIn]; Dietrich, Undine [VerfasserIn]; Möhn, Till [VerfasserIn]; Kießling, Tobias R. [VerfasserIn]; Pawlizak, Steve [VerfasserIn]; Fritsch, Anatol W. [VerfasserIn]; Horn, Lars-Christian [VerfasserIn]; Briest, Susanne [VerfasserIn]; Höckel, Michael [VerfasserIn]; Zink, Mareike [VerfasserIn]; Käs, Josef A. [VerfasserIn]

Cell membrane softening in human breast and cervical cancer cells

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  • Medientyp: E-Artikel
  • Titel: Cell membrane softening in human breast and cervical cancer cells
  • Beteiligte: Händel, Chris [VerfasserIn]; Schmidt, B.U. Sebastian [VerfasserIn]; Schiller, Jürgen [VerfasserIn]; Dietrich, Undine [VerfasserIn]; Möhn, Till [VerfasserIn]; Kießling, Tobias R. [VerfasserIn]; Pawlizak, Steve [VerfasserIn]; Fritsch, Anatol W. [VerfasserIn]; Horn, Lars-Christian [VerfasserIn]; Briest, Susanne [VerfasserIn]; Höckel, Michael [VerfasserIn]; Zink, Mareike [VerfasserIn]; Käs, Josef A. [VerfasserIn]
  • Erschienen: Bristol: IOP Publishing, [2022]
  • Erschienen in: New Journal of Physics ; 17, (2015)
  • Sprache: Englisch
  • Schlagwörter: cancer ; membrane rigidity ; biomembranes
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Biomechanical properties are key to many cellular functions such as cell division and cell motility andthus are crucial in the development and understanding of several diseases, for instance cancer. Themechanics of the cellular cytoskeleton have been extensively characterized in cells and artificialsystems. The rigidity of the plasma membrane, with the exception of red blood cells, is unknown andmembrane rigidity measurements only exist for vesicles composed of a few synthetic lipids. In thisstudy, thermal fluctuations of giant plasma membrane vesicles (GPMVs) directly derived from theplasma membranes of primary breast and cervical cells, as well as breast cell lines, are analyzed. Cellblebs or GPMVs were studied via thermal membrane fluctuations and mass spectrometry. It will beshown that cancer cell membranes are significantly softer than their non-malignant counterparts. Thiscan be attributed to a loss of fluid raft forming lipids in malignant cells. These results indicate that thereduction of membrane rigidity promotes aggressive blebbing motion in invasive cancer cells.
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)