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Schorling, Ruth Maria [VerfasserIn]; Pfrepper, Christian [VerfasserIn]; Golombek, Thomas [VerfasserIn]; Cella, Chiara Alessandra [VerfasserIn]; Muñoz-Unceta, Nerea [VerfasserIn]; Siegemund, Roland [VerfasserIn]; Engel, Christoph [VerfasserIn]; Petros, Sirak [VerfasserIn]; Lordick, Florian [VerfasserIn]; Knödler, Maren [VerfasserIn]

Evaluation of Biomarkers for the Prediction of Venous Thromboembolism in Ambulatory Cancer Patients

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  • Medientyp: E-Artikel
  • Titel: Evaluation of Biomarkers for the Prediction of Venous Thromboembolism in Ambulatory Cancer Patients
  • Beteiligte: Schorling, Ruth Maria [VerfasserIn]; Pfrepper, Christian [VerfasserIn]; Golombek, Thomas [VerfasserIn]; Cella, Chiara Alessandra [VerfasserIn]; Muñoz-Unceta, Nerea [VerfasserIn]; Siegemund, Roland [VerfasserIn]; Engel, Christoph [VerfasserIn]; Petros, Sirak [VerfasserIn]; Lordick, Florian [VerfasserIn]; Knödler, Maren [VerfasserIn]
  • Erschienen: Basel: Karger, [2023]
  • Erschienen in: Oncology research and treatment ; 43,9 (2020), Seite 414-426
  • Sprache: Englisch
  • Schlagwörter: Cholangiocarcinoma ; Risk assessment models ; Biomarkers ; Venous thromboembolism ; D-dimer
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Background: Venous thromboembolism (VTE) is a common complication of cancer. This study aimed to evaluate immature platelet fraction (IPF), mean platelet volume (MPV), P-selectin, D-dimer, and thrombin generation (TG) as predictive biomarkers for VTE and further the improvement of existing risk assessment models (RAMs). Methods: A prospective, observational, exploratory study was conducted on ambulatory cancer patients with indication for systemic chemotherapy. Baseline RAMs included the Khorana-, Vienna Cancer, Thrombosis-, Protecht-, ONKOTEV-, and Catscore. IPF, MPV, P-selectin, D-dimer, and TG were analysed at baseline and 3-month follow-up. Results: We enrolled 100 patients, of whom 89 completed the follow-up. Frequent tumour types were breast (30%), gastric (14%), gynaecological (14%), and colorectal (14%) cancer. Ten of the 89 patients (11.2%) developed VTE. The highest VTE rate was observed in patients with cholangiocarcinoma (3/5; 60%). Baseline D-dimer levels but not IPF, MPV, or P-selectin were associated with the risk of developing VTE (HR 6.9; p = 0.021). None of the RAMs showed statistical significance in predicting VTE. Peak thrombin and endogenous thrombin potential were lower in patients who developed VTE. Biomarker changes between baseline and follow-up were not associated with VTE risk. Conclusions: VTE risk was well predicted by baseline D-dimer levels. Adding D-dimer could improve existing RAMs to better identify patients who may benefit from primary VTE prophylaxis. The VTE risk among patients with cholangiocarcinoma should be further evaluated
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Urheberrechtsschutz