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Huang, Jue [Verfasser:in]; Mauche, Nicole [Verfasser:in]; Rullmann, Michael [Verfasser:in]; Ulke, Christine [Verfasser:in]; Becker, Georg-Alexander [Verfasser:in]; Patt, Marianne [Verfasser:in]; Zientek, Franziska [Verfasser:in]; Hesse, Swen [Verfasser:in]; Sabri, Osama [Verfasser:in]; Strauß, Maria [Verfasser:in]

Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)

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  • Medientyp: E-Artikel
  • Titel: Association between Individual Norepinephrine Transporter (NET) Availability and Response to Pharmacological Therapy in Adults with Attention-Deficit/Hyperactivity Disorder (ADHD)
  • Beteiligte: Huang, Jue [Verfasser:in]; Mauche, Nicole [Verfasser:in]; Rullmann, Michael [Verfasser:in]; Ulke, Christine [Verfasser:in]; Becker, Georg-Alexander [Verfasser:in]; Patt, Marianne [Verfasser:in]; Zientek, Franziska [Verfasser:in]; Hesse, Swen [Verfasser:in]; Sabri, Osama [Verfasser:in]; Strauß, Maria [Verfasser:in]
  • Erschienen: Basel: MDPI, [2023]
  • Erschienen in: Brain Sciences ; 12, (2022)
  • Sprache: Englisch; Deutsch
  • Schlagwörter: comorbidity ; ADHD ; non-stimulant ; follow-up ; psychostimulant ; anxiety ; depression ; therapy response
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Background: The role of the norepinephrine transporter (NET) has received increased focusin recent studies on the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). The predictive value for pharmacological treatment and its link to other health or social limitations has beenlittle-studied. This follow-up research on adult patients with ADHD aimed to explore whether thetherapy response and health and social impairments depend on baseline individual NET availability.Methods: Data were collected from 10 patients on personal, family and professional situations, mentaland physical health and treatments received after baseline via online and telephone surveys andwere compared to baseline data to evaluate treatment-related changes. Results: The majority of ourADHD patients did not show therapy responses but showed improvements due to pharmacologicaltreatment. There was no evidence of relationships between pre-treatment NET availability andtherapy response or health/social limitations. Conclusions: Pharmacological monotherapy wasinsufficient to promote symptom remission, especially for participants with extreme insufficiencyin NET availability, but improved outcomes in academic and social functioning. Psychotherapyshould be considered as an add-on to the standard treatment approach due to its positive outcomein reducing social limitations. The prognostic value of individual NET availability in predicting theresponse to therapy needs further studies with large sample sizes
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)