Adult Medulloblastoma : Updates on Current Management and Future Perspectives

Medientyp: E-Artikel

Titel: Adult Medulloblastoma : Updates on Current Management and Future Perspectives

Beteiligte: Franceschi, Enrico [Verfasser:in]; Giannini, Caterina [Verfasser:in]; Furtner, Julia [Verfasser:in]; Pajtler, Kristian W. [Verfasser:in]; Asioli, Sofia [Verfasser:in]; Guzman, Raphael [Verfasser:in]; Seidel, Clemens [Verfasser:in]; Gatto, Lidia [Verfasser:in]; Hau, Peter [Verfasser:in]

Erschienen: Basel: MDPI, [2023]

Sprache: Englisch

DOI: 10.3390/cancers14153708

Schlagwörter: SHH inhibitors ; sonidegib ; vismodegib ; neurosurgery ; medulloblastoma ; sonic hedgehog (SHH) ; SHH pathway ; targeted therapy ; radiotherapy ; chemotherapy

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Beschreibung: Medulloblastoma (MB) is a malignant embryonal tumor of the posterior fossa belonging tothe family of primitive neuro-ectodermic tumors (PNET). MB generally occurs in pediatric age, but in14–30% of cases, it affects the adults, mostly below the age of 40, with an incidence of 0.6 per millionper year, representing about 0.4–1% of tumors of the nervous system in adults. Unlike pediatric MB,robust prospective trials are scarce for the post-puberal population, due to the low incidence of MB inadolescent and young adults. Thus, current MB treatments for older patients are largely extrapolatedfrom the pediatric experience, but the transferability and applicability of these paradigms to adultsremain an open question. Adult MB is distinct from MB in children from a molecular and clinicalperspective. Here, we review the management of adult MB, reporting the recent published literaturefocusing on the effectiveness of upfront chemotherapy, the development of targeted therapies, andthe potential role of a reduced dose of radiotherapy in treating this disease.

Zugangsstatus: Freier Zugang

Rechte-/Nutzungshinweise: Namensnennung (CC BY)

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