> Detailanzeige

Löhr, Mario [Verfasser:in]; Härtig, Wolfgang [Verfasser:in]; Schulze, Almut [Verfasser:in]; Kroiß, Matthias [Verfasser:in]; Sbiera, Silviu [Verfasser:in]; Lapa, Constantin [Verfasser:in]; Mages, Bianca [Verfasser:in]; Strobel, Sabrina [Verfasser:in]; Hundt, Jennifer Elisabeth [Verfasser:in]; Bohnert, Simone [Verfasser:in]; Kircher, Stefan [Verfasser:in]; Janaki-Raman, Sudha [Verfasser:in]; Monoranu, Camelia-Maria [Verfasser:in]

SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?
  • Beteiligte: Löhr, Mario [Verfasser:in]; Härtig, Wolfgang [Verfasser:in]; Schulze, Almut [Verfasser:in]; Kroiß, Matthias [Verfasser:in]; Sbiera, Silviu [Verfasser:in]; Lapa, Constantin [Verfasser:in]; Mages, Bianca [Verfasser:in]; Strobel, Sabrina [Verfasser:in]; Hundt, Jennifer Elisabeth [Verfasser:in]; Bohnert, Simone [Verfasser:in]; Kircher, Stefan [Verfasser:in]; Janaki-Raman, Sudha [Verfasser:in]; Monoranu, Camelia-Maria [Verfasser:in]
  • Erschienen: Basel: MDPI, [2024]
  • Erschienen in: International Journal of Molecular Sciences ; 23, (2022)
  • Sprache: Englisch
  • Schlagwörter: mitotane ; IDH1/2 ; SOAT1 ; targeted therapy ; astrocytoma ; glioblastoma ; lipid droplets
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Targeting molecular alterations as an effective treatment for isocitrate dehydrogenasewildtypeglioblastoma (GBM) patients has not yet been established. Sterol-O-Acyl Transferase 1(SOAT1), a key enzyme in the conversion of endoplasmic reticulum cholesterol to esters for storage inlipid droplets (LD), serves as a target for the orphan drug mitotane to treat adrenocortical carcinoma.Inhibition of SOAT1 also suppresses GBM growth. Here, we refined SOAT1-expression in GBMand IDH-mutant astrocytoma, CNS WHO grade 4 (HGA), and assessed the distribution of LD inthese tumors. Twenty-seven GBM and three HGA specimens were evaluated by multiple GFAP,Iba1, IDH1 R132H, and SOAT1 immunofluorescence labeling as well as Oil Red O staining. Toa small extent SOAT1 was expressed by tumor cells in both tumor entities. In contrast, strongexpression was observed in glioma-associated macrophages. Triple immunofluorescence labelingrevealed, for the first time, evidence for SOAT1 colocalization with Iba1 and IDH1 R132H, respectively.Furthermore, a notable difference in the amount of LD between GBM and HGA was observed.Therefore, SOAT1 suppression might be a therapeutic option to target GBM and HGA growth andinvasiveness. In addition, the high expression in cells related to neuroinflammation could be beneficialfor a concomitant suppression of protumoral microglia/macrophages.
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)