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Almeida, Antonio M. [Verfasser:in]; Prebet, Thomas [Verfasser:in]; Itzykson, Raphael [Verfasser:in]; Ramos, Fernando [Verfasser:in]; Al-Ali, Haifa [Verfasser:in]; Shammo, Jamile [Verfasser:in]; Pinto, Ricardo [Verfasser:in]; Maurillo, Luca [Verfasser:in]; Wetzel, Jaime [Verfasser:in]; Musto, Pellegrino [Verfasser:in]; van de Loosdrecht, Arjan A. [Verfasser:in]; Joao Costa, Maria [Verfasser:in]; Esteves, Susana [Verfasser:in]; Burgstaller, Sonja [Verfasser:in]; Stauder, Reinhard [Verfasser:in]; Autzinger, Eva M. [Verfasser:in]; Lang, Alois [Verfasser:in]; Krippl, Peter [Verfasser:in]; Geissler, Dietmar [Verfasser:in]; Falantes, Jose Francisco [Verfasser:in]; Pedro, Carmen [Verfasser:in]; Bargay, Joan [Verfasser:in]; Deben, Guillermo [Verfasser:in]; Garrido, Ana [Verfasser:in]; [...]

Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study

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  • Medientyp: E-Artikel
  • Titel: Clinical Outcomes of 217 Patients with Acute Erythroleukemia According to Treatment Type and Line: A Retrospective Multinational Study
  • Beteiligte: Almeida, Antonio M. [Verfasser:in]; Prebet, Thomas [Verfasser:in]; Itzykson, Raphael [Verfasser:in]; Ramos, Fernando [Verfasser:in]; Al-Ali, Haifa [Verfasser:in]; Shammo, Jamile [Verfasser:in]; Pinto, Ricardo [Verfasser:in]; Maurillo, Luca [Verfasser:in]; Wetzel, Jaime [Verfasser:in]; Musto, Pellegrino [Verfasser:in]; van de Loosdrecht, Arjan A. [Verfasser:in]; Joao Costa, Maria [Verfasser:in]; Esteves, Susana [Verfasser:in]; Burgstaller, Sonja [Verfasser:in]; Stauder, Reinhard [Verfasser:in]; Autzinger, Eva M. [Verfasser:in]; Lang, Alois [Verfasser:in]; Krippl, Peter [Verfasser:in]; Geissler, Dietmar [Verfasser:in]; Falantes, Jose Francisco [Verfasser:in]; Pedro, Carmen [Verfasser:in]; Bargay, Joan [Verfasser:in]; Deben, Guillermo [Verfasser:in]; Garrido, Ana [Verfasser:in]; [...]
  • Erschienen: Basel: MDPI, [2024]
  • Erschienen in: International Journal of Molecular Sciences ; 18, (2017)
  • Sprache: Englisch
  • Schlagwörter: acute erythroleukemia ; decitabine ; azacitidine
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Acute erythroleukemia (AEL) is a rare disease typically associated with a poor prognosis.Themedian survival ranges between 3–9months frominitial diagnosis. Hypomethylating agents (HMAs)have been shown to prolong survival in patients with myelodysplastic syndromes (MDS) and AML,but there is limited data of their efficacy in AEL. We collected data from 210 AEL patients treated at28 international sites. Overall survival (OS) and PFS were estimated using the Kaplan-Meier methodand the log-rank test was used for subgroup comparisons. Survival between treatment groups wascompared using the Cox proportional hazards regression model. Eighty-eight patients were treated withHMAs, 44 front line, and 122 with intensive chemotherapy (ICT). ICT led to a higher overall responserate (complete or partial) compared to first-line HMA (72% vs. 46.2%, respectively; p0.001), but similarprogression-free survival (8.0 vs. 9.4 months; p = 0.342). Overall survival was similar for ICT vs. HMAs(10.5 vs. 13.7months; p = 0.564), but patients with high-risk cytogenetics treated with HMA first-line livedlonger (7.5 for ICT vs. 13.3 months; p = 0.039). Our results support the therapeutic value of HMA in AEL.
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)