> Detailanzeige

Feldbrügge, Linda [Verfasser:in]; Splith, Katrin [Verfasser:in]; Kämmerer, Ines [Verfasser:in]; Richter, Sandra [Verfasser:in]; Riddermann, Anna [Verfasser:in]; Ortiz Galindo, Santiago Andres [Verfasser:in]; Krenzien, Felix [Verfasser:in]; Müller, Tobias [Verfasser:in]; Csizmadia, Eva [Verfasser:in]; Pratschke, Johann [Verfasser:in]; Robson, Simon C. [Verfasser:in]; Schmelzle, Moritz [Verfasser:in]

Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity

Literatur-
verwaltung

Zur
Merkliste

Lösche von
Merkliste

Per Whatsapp teilen

Schließen

Merkliste



Sie können Bookmarks mittels Listen verwalten, loggen Sie sich dafür bitte in Ihr SLUB Benutzerkonto ein.
  • Medientyp: E-Artikel
  • Titel: Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity
  • Beteiligte: Feldbrügge, Linda [Verfasser:in]; Splith, Katrin [Verfasser:in]; Kämmerer, Ines [Verfasser:in]; Richter, Sandra [Verfasser:in]; Riddermann, Anna [Verfasser:in]; Ortiz Galindo, Santiago Andres [Verfasser:in]; Krenzien, Felix [Verfasser:in]; Müller, Tobias [Verfasser:in]; Csizmadia, Eva [Verfasser:in]; Pratschke, Johann [Verfasser:in]; Robson, Simon C. [Verfasser:in]; Schmelzle, Moritz [Verfasser:in]
  • Erschienen: Basel: MDPI, [2024]
  • Erschienen in: International Journal of Molecular Sciences ; 21, (2020)
  • Sprache: Englisch
  • Schlagwörter: purinergic signaling ; Entpd2 ; NTPDase2 ; APAP hepatotoxicity
  • Entstehung:
  • Anmerkungen:
  • Beschreibung: Ecto-nucleotidase triphosphate diphosphohydrolase-2 (NTPDase2) is an ecto-enzyme thatis expressed on portal fibroblasts in the liver that modulates P2 receptor signaling by regulatinglocal concentrations of extracellular ATP and ADP. NTPDase2 has protective properties in liverfibrosis and may impact bile duct epithelial turnover. Here, we study the role of NTPDase2 in acuteliver injury using an experimental model of acetaminophen (APAP) intoxication in mice with globaldeletion of NTPDase2. Acute liver toxicity was caused by administration of acetaminophen in wildtype (WT) and NTPDase2-deficient (Entpd2 null) mice. The extent of liver injury was comparedby histology and serum alanine transaminase (ALT). Markers of inflammation, regeneration andfibrosis were determined by qPCR). We found that Entpd2 expression is significantly upregulatedafter acetaminophen-induced hepatotoxicity. Entpd2 null mice showed significantly more necrosisand higher serum ALT compared to WT. Hepatic expression of IL-6 and PDGF-B are higher in Entpd2null mice. Our data suggest inducible and protective roles of portal fibroblast-expressed NTPDase2in acute necrotizing liver injury. Further studies should investigate the relevance of these purinergicpathways in hepatic periportal and sinusoidal biology as such advances in understanding mightprovide possible therapeutic targets.
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)