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Pillunat, Karin R. [VerfasserIn]; Kocket, Greta A. [VerfasserIn]; Herber, Robert [VerfasserIn]; Jasper, Carolin S. [VerfasserIn]; Lenk, Janine [VerfasserIn]; Pillunat, Lutz E. [VerfasserIn]

Efficacy of selective laser trabeculoplasty on lowering intraocular pressure fluctuations and nocturnal peak intraocular pressure in treated primary open-angle glaucoma patients

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  • Medientyp: E-Artikel
  • Titel: Efficacy of selective laser trabeculoplasty on lowering intraocular pressure fluctuations and nocturnal peak intraocular pressure in treated primary open-angle glaucoma patients
  • Beteiligte: Pillunat, Karin R. [VerfasserIn]; Kocket, Greta A. [VerfasserIn]; Herber, Robert [VerfasserIn]; Jasper, Carolin S. [VerfasserIn]; Lenk, Janine [VerfasserIn]; Pillunat, Lutz E. [VerfasserIn]
  • Erschienen: Berlin ; Heidelberg : Springer, [2024]
  • Sprache: Englisch
  • DOI: 10.1007/s00417-022-05897-y
  • Schlagwörter: Nocturnal peak IOP ; 24-stündige IOD-Fluktuation ; zirkadiane Spannungskurven ; 24-h IOP fluctuation ; Circadian tension curves ; nächtlicher Spitzen-IOD ; medicine ; Selektive Lasertrabekuloplastik ; Medizin ; Selective laser trabeculoplasty
  • Entstehung:
  • Anmerkungen: Hinweis: Link zum Artikel der zuerst in der Zeitschrift 'Graefe's archive for clinical and experimental ophthalmology' bei Springer Link erschienen ist. DOI: 10.1007/s00417-022-05897-y
  • Beschreibung: Purpose To investigate the efficacy of adjunctive selective laser trabeculoplasty (SLT) in reducing 24-h intraocular pressure (IOP) fluctuations and nocturnal IOP peaks. Methods In this prospective interventional case series, 157 medically treated eyes of 157 patients with primary open-angle glaucoma (POAG) who were assigned SLT to further reduce IOP were consecutively included. Each patient had a complete glaucoma work-up and 24-h IOP monitoring (6 measurements, including one in the supine position) taken before and on average 6 months after SLT. The main outcome measures were the reduction of 24-h IOP fluctuations and nocturnal peak IOP. Secondary outcome measures were success rates, factors influencing the reduction of high 24-h IOP fluctuations and nocturnal peak IOP, complications, and severe adverse events. Results Medicated mean 24-h IOP (mmHg) was statistically significantly reduced from 15.1 ± 2.6 to 13.8 ± 2.4 (P < 0.001) and IOP fluctuations from 6.5 ± 2.7 to 5.4 ± 2.6 (P < 0.001) 6 months after SLT. Ninety-four eyes (59.9%) initially had high IOP fluctuations (more than 5 mmHg). These were reduced from 8.1 ± 2.3 to 5.6 ± 2.7 at 6 months (P < 0.001). Fifty-two eyes (55.3%) had fluctuations below 5 mmHg post-SLT which was defined as success. Fifty-one patients (32.5%) had nocturnal IOP peaks. In these cases, nocturnal IOP was reduced by 19.2% from 20.1 ± 3.4 to 16.2 ± 3.3 mmHg at 6 months (P = 0.001). Conclusions The current study demonstrates that adjunctive SLT not only reduces mean 24-h IOP in treated POAG patients, but also has an additional benefit in reducing IOP fluctuations and nocturnal peak IOP.
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)