• Medientyp: E-Artikel
  • Titel: KS0365, a novel activator of the transient receptor potential vanilloid 3 (TRPV3) channel, accelerates keratinocyte migration
  • Beteiligte: Maier, Marion [Verfasser:in]; Olthoff, Stefan [Verfasser:in]; Hill, Kerstin [Verfasser:in]; Zosel, Carolin [Verfasser:in]; Magauer, Thomas [Verfasser:in]; Wein, Lukas Anton [Verfasser:in]; Schaefer, Michael [Verfasser:in]
  • Erschienen: Malden: Wiley, [2024]
  • Erschienen in: British journal of pharmacology ; 179,24 (2022), Seite 5290-5304
  • Sprache: Englisch
  • DOI: 10.1111/bph.15937
  • Schlagwörter: TRPV3 ; wound healing ; leading edge ; keratinocyte migration
  • Entstehung:
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  • Beschreibung: KS0365 activated recombinant and native mouse TRPV3 more potentlyand with a higher efficacy compared with 2-APB and did not activate TRPV2 orTRPV4 channels. The activation of TRPV3 by KS0365 super-additively acceleratedthe EGF-induced keratinocyte migration, which was inhibited by the TRP channelblocker ruthenium red or by siRNA-mediated TRPV3 knockdown. Moreover, KS0365induced strong Ca2+ responses in migrating front cells and in leading edges of keratinocytes.
  • Zugangsstatus: Freier Zugang
  • Rechte-/Nutzungshinweise: Namensnennung (CC BY)