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Medientyp:
E-Artikel
Titel:
Bacterial DUBs: deubiquitination beyond the seven classes
Beteiligte:
Hermanns, Thomas;
Hofmann, Kay
Erschienen:
Portland Press Ltd., 2019
Erschienen in:
Biochemical Society Transactions, 47 (2019) 6, Seite 1857-1866
Sprache:
Englisch
DOI:
10.1042/bst20190526
ISSN:
0300-5127;
1470-8752
Entstehung:
Anmerkungen:
Beschreibung:
Protein ubiquitination is a posttranslational modification that regulates many aspects of cellular life, including proteostasis, vesicular trafficking, DNA repair and NF-κB activation. By directly targeting intracellular bacteria or bacteria-containing vacuoles to the lysosome, ubiquitination is also an important component of cell-autonomous immunity. Not surprisingly, several pathogenic bacteria encode deubiquitinases (DUBs) and use them as secreted effectors that prevent ubiquitination of bacterial components. A systematic overview of known bacterial DUBs, including their cleavage specificities and biological roles, suggests multiple independent acquisition events from host-encoded DUBs and other proteases. The widely used classification of DUBs into seven well-defined families should only be applied to eukaryotic DUBs, since several bacterial DUBs do not follow this classification.