Blood Flow Assessment by Ultrasound‐Induced Destruction of Echocontrast Agents Using Harmonic Power Doppler Imaging: Which Parameters Determine Contrast Replenishment Curves?
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Medientyp:
E-Artikel
Titel:
Blood Flow Assessment by Ultrasound‐Induced Destruction of Echocontrast Agents Using Harmonic Power Doppler Imaging: Which Parameters Determine Contrast Replenishment Curves?
Erschienen in:
Echocardiography, 18 (2001) 1, Seite 1-8
Sprache:
Englisch
DOI:
10.1046/j.1540-8175.2001.00001.x
ISSN:
1540-8175;
0742-2822
Entstehung:
Anmerkungen:
Beschreibung:
<jats:p>Objective: To evaluate the feasibility of flow determinations by contrast replenishment using harmonic power Doppler imaging (H‐PDI). Background: The application of indicator dilution principles on contrast echocardiography is limited by numerous methodical problems. Recently, a new method was introduced that relies on ultrasound‐mediated microbubble destruction and evaluation of the contrast replenishment. Methods: Definity, a perfluorocarbon‐derived contrast agent under development, was continuously infused into a steady flow phantom and H‐PDI registrations were performed within a silicone tube (<jats:styled-content>d = 8 mm</jats:styled-content>). Replenishment interval between destruction and imaging frame was varied from 0.04–2 seconds. Nonlinear curve fitting was performed using an exponential mathematical model. Results: Strong linear correlation between contrast dose and maximum signal intensity as well as between flow and the slope variable β of the replenishment curve was found for all settings (<jats:styled-content>r > 0.96</jats:styled-content>). Maximum signal intensity and contrast replenishment rate were found to be a function of emission power and were significantly influenced by depth and focus position. Conclusion: The feasibility of flow assessment using replenishment curves obtained by H‐PDI was demonstrated. However, in experimental conditions, flow analysis was severely influenced by ultrasound system settings and imaging conditions such as emission power, sound field geometry, and investigation depth. For a clinical use of this promising approach, algorithms that take specific system settings and imaging conditions into account have to be found. Imaging modalities that enable a most homogeneous scan field are best suited for the assessment of contrast replenishment.</jats:p>